A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Understanding early triggers of Cystic Fibrosis Lung Disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Determinants of culture success through retrospective analysis of a program of routinely brushing children with Cystic Fibrosis airway disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

Biodiesel is a generic term for fuel that can be made from virtually any plant or animal oil via transesterification of triglycerides with an alcohol... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• July 2015

Asthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• May 2011

Authors: Berry LJ, Sheil B, Garratt L, Sly PD. Authors notes: Journal of Cystic Fibrosis 2010;9:346-50. Keywords: interleukin 8, neutrophil elastase, bronchoalveolar lavage fluid Abstract: Interleukin-8 (IL-8) and neutrophil elastase (NE) are ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• September 2010

Prader-Willi syndrome (PWS) is a rare genetic disorder characterised by neurodevelopmental delays, hyperphagia, difficulties with social communication and challenging behaviours. Individuals require intensive supervision from caregivers which may negatively affect caregiver quality of life. This study used data collected in the Australasian PWS Registry to evaluate associations between child behaviours and caregiver mental well-being. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

In this translational review, the mechanisms, roles, and impact of epithelial-mesenchymal transition in chronic lung diseases are discussed ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Here we examine the latest findings of neutrophils in pediatric CF lung disease and proposed mechanisms of their pathogenicity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Neutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Staphylococcus aureus (S. aureus) infections are notoriously complicated by the ability of the organism to grow in biofilms and are difficult to eradicate with antimicrobial therapy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021