Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

The risks of adverse obstetric outcomes among young women survivors of colorectal cancer (CRC) are uncertain. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

In this sub-study, we aimed to investigate factors that may have influenced study participation and completeness of survey completion. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

There is a 30% higher case fatality rate from cancer in psychiatric patients even though their incidence of cancer is no greater than in the general population. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• February 2013

Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

disease-deconvolution" identified associations between the parasite-brain interactions and epilepsy, movement disorders, Alzheimer's disease, and cancer. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

In adults, the unpredictability of voriconazole pharmacokinetics, particularly in those patients receiving chemotherapy, is well recognised. A paucity of... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Given that the transcriptional regulatory activity of estrogen receptor (ER) is modulated by its biochemical cofactors, genetic variation within the ER... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• August 2012

Evidence suggests the involvement of the microbiota, including oral, intra-tumoral and gut, in pancreatic cancer progression and response to therapy. The gut microbiota modulates the bile acid pool and is associated with maintaining host physiology. Studies have shown that the bile acid/gut microbiota axis is dysregulated in pancreatic cancer. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the role of individual subtypes remains unclear. Here we systematically compared the capacity of distinct type I IFN subtypes to enhance T cell responses to a whole-cell vaccination strategy in a pre-clinical murine model. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

The goal of a clinical quality registry is to deliver immediate gains in survival and quality of life by delivering timely feedback to practitioners, thereby ensuring every patient receives the best existing treatment. We are developing an Australian Brain Cancer Registry (ABCR) to identify, describe, and measure the impact of the variation and gaps in brain cancer care from the time of diagnosis to the end of life. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

This study asked consumers (patients, carers) and healthcare professionals (HCPs) to identify the most important symptoms for adults with cancer and potential treatment interventions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023