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        13-24 of 1593 results for 'Council'

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        Modulation of the postnatal maturation of immune function during early life: studies on the effects of natural infections and exposure to the bacterial-derived immunoenhancer OM85

        Severe winter lower respiratory infections in early life are known to be major risk factors for subsequent development of asthma, and it is also known that the high susceptibility to these infections in infants is due to the functional immaturity of ...

        Research

        Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

        Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations. ...

        Research

        Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

        Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. ...

        Research

        Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezing

        Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses. ...

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        Treatment Outcomes among Pregnant Patients with Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis

        The management of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes. ...

        Research

        Anti-CD47 immunotherapy for medulloblastoma and high-grade glioma

        Raelene Nick Endersby Gottardo R NG BSc (Hons) PhD MBChB FRACP PhD Brainchild Fellow; Co-Head, Brain Tumour Research Co-Head, Brain Tumour Research raelene.endersby@telethonkids.org.au nicholas.gottardo@telethonkids.org.au Co-Head, Brain Tumour ...

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        Global distribution of human hookworm species and differences in their morbidity effects: a systematic review

        The global distribution and morbidity effects for each specific hookworm species is unknown, which prevents implementation of the optimum intervention for local hookworm control. ...

        Research

        Down syndrome and leukemia: from basic mechanisms to clinical advances

        Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades. ...

        Research

        Defining Age-specific Relationships of Respiratory Syncytial Virus and Rhinovirus Species in Hospitalized Children With Acute Wheeze

        Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species C are implicated in the majority of these presentations. However, the relative importance and age-specificities of these viruses have not been defined. ...

        Research

        Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

        Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. ...

        Research

        Increased nasal Streptococcus pneumoniae presence in Western environment associated with allergic conditions in Chinese immigrants

        Chinese immigrants living in Australia experience increased allergic conditions: asthma, eczema, hay fever and wheeze. Recently we reported diminished innate cytokine responses in long-term immigrants, potentially increasing their pathogenic viral load and microbial carriage. We hypothesise that a Western environment changes the nasal microbiome profile, and this altered profile may be associated with the development of allergic conditions. In this cross-sectional study, we aimed to examine the loading of viral and microbial respiratory pathogens in the upper airway. ...

        Research

        A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

        Here we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia ...

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