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        13-24 of 151 results for 'animal research'

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        CD4 allergen tetramers

        The introduction of class II tetramers for identifying antigen-binding CD41 cells has lagged behind the use of class I tetramers because of difficulties... ...

        Research

        Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank

        Maternal immune activation and prenatal maternal stress are well-studied risk factors for psychiatric conditions such as autism and schizophrenia. Animal studies have proposed the gut microbiome as a mechanism underlying this association and have found that risk factor-related gut microbiome alterations persist in the adult offspring. ...

        Research

        Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial

        The importance of lung recruitment before surfactant administration has been shown in animal studies. Well designed trials in preterm infants are absent. We aimed to examine whether the application of a recruitment manoeuvre just before surfactant administration, followed by rapid extubation (intubate-recruit-surfactant-extubate [IN-REC-SUR-E]), decreased the need for mechanical ventilation during the first 72 h of life compared with no recruitment manoeuvre (ie, intubate-surfactant-extubate [IN-SUR-E]). ...

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        Innate affairs of allergens

        Activation of receptors of the innate immune system is a critical step in the initiation of immune responses. ...

        Research

        Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea

        Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared a lentiviral vector (LV) carrying... ...

        Research

        Computational fluid-particle dynamic and pharmacokinetic assessment of electronic cigarette aerosols for improved understanding of their potential to impact health

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

        Research

        Identification of Der p 23, a peritrophin-like protein, as a new major dermatophagoides pteronyssinus allergen

        The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. ...

        Research

        Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA

        Aneuploidies, and in particular, trisomies represent the most common genetic aberrations observed in human genetics today. To explore the presence of trisomies in historic and prehistoric populations we screen nearly 10,000 ancient human individuals for the presence of three copies of any of the target autosomes. We find clear genetic evidence for six cases of trisomy 21 (Down syndrome) and one case of trisomy 18 (Edwards syndrome), and all cases are present in infant or perinatal burials. ...

        Research

        House dust allergy and immunotherapy

        HDM allergy is associated with asthma, allergic rhinitis and atopic dermatitis. ...

        Research

        The advent of recombinant allergens and allergen cloning Authors:

        When the allergen nomenclature system was adopted in 1986, allergens were identified by their behavior on electrophoresis and chromatography... ...

        Research

        Recombinant house dust mite allergens

        House dust mites (HDM) are a globally important source of allergen responsible for the sensitization of more than 50% of allergic patients. ...

        Research

        The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

        Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1 ...

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