Jonathan Carapetis AM JR AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@telethonkids.org.au Institute Director; Head, Strep A Translation; Co-Founder of REACH Professor ...

• 1. Telethon Kids Institute
• Projects

We explore young Aboriginal people's and clinicians' experience of injection pain for the 10 years of penicillin injections young people are prescribed. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

A 7-year old boy developed myositis secondary to intramuscular injection of benzathine penicillin-G in the context of secondary prophylaxis for RF ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

In Western Australia, Neisseria meningitidis serogroup W clonal complex 11 became the predominant cause of invasive meningococcal disease in 2016 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Syphilis is an important global health threat and little has changed in its treatment since the mid-20th century. For late-latent or syphilis infection of unknown duration, the standard treatment of multiple intramuscular injections of benzathine penicillin G (BPG) are associated with significant pain and distress to clients and caregivers, negatively impacting on treatment completion. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• March 2024

Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability, and target exposure profiles of BPG injection are key knowledge gaps for RHD control. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Jonathan Carapetis AM JR AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@telethonkids.org.au Institute Director; Head, Strep A Translation; Co-Founder of REACH Professor ...

• 1. Telethon Kids Institute
• Projects

A sample target product profile for reformulated benzathine penicillin G is presented ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Regular intramuscular (i.m.) benzathine penicillin G (BPG) injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. Patient adherence to IM BPG is poor, largely due to pain, the need for regular injections every 3-4 weeks and health sector delivery challenges in resource-limited settings. There is an urgent need for new approaches for secondary prophylaxis, such as an implant which could provide sustained penicillin concentrations for more than 6 months. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Our local data supports continuing intramuscular injection of BPG in patients with rheumatic heart disease receiving anticoagulant medication ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Rheumatic heart disease (RHD) remains the leading cause of cardiac-related deaths and disability in children and young adults worldwide. In The Gambia, the RHD burden is thought to be high although no data are available and no control programme is yet implemented. We conducted a pilot study to generate baseline data on the clinical and valvular characteristics of RHD patients at first presentation, adherence to penicillin prophylaxis and the evolution of lesions over time. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Benzathine penicillin G is an important antibiotic for the treatment and prevention of group A streptococcal infections associated with rheumatic fever and... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• September 2013