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        Anaesthesia, pain and recovery profiles in children following dental extractions

        The aim of this prospective cohort study was to describe the anaesthetic practices, rates of postoperative pain and the recovery trajectory of children having urgent dental extractions at our institution. ...

        Research

        The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

        Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease ...

        Research

        Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients

        Our data illustrate that rhinovirus infection is capable of infecting upper and lower airway epithelial cells, driving cell death and inflammation ...

        Research

        Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host Interactomes

        Genome sequencing and phylogenetic analysis of a quorum sensing positive Psychrobacter isolate identified several quorum sensing associated systems ...

        Research

        The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

        Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection ...

        Research

        Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

        These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease ...

        Research

        Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies

        A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF ...

        Research

        Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

        To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls. ...

        Research

        Airway surface liquid pH is not acidic in children with cystic fibrosis

        Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

        Research

        DEFEND CF: Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosis

        Stephen Graham Stick Hall SM GL MB BChir PhD MRCP FRACP BAppSci PhD CRFS FANZSRS FThorSoc FERS Head, P4 Respiratory Health for Kids Honorary Research Associate Head, P4 Respiratory Health for Kids Honorary Research Associate Areas for research ...

        Research

        Differential cell counts using center-point networks achieves human-level accuracy and efficiency over segmentation

        Differential cell counts is a challenging task when applying computer vision algorithms to pathology. Existing approaches to train cell recognition require high availability of multi-class segmentation and/or bounding box annotations and suffer in performance when objects are tightly clustered. ...

        Research

        Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

        Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure ...

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