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        229-240 of 521 results for 'Growth'

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        The dystroglycan receptor maintains glioma stem cells in the vascular niche

        These findings reveal a central role of the DG receptor, not only as a structural element, but also as a critical factor promoting mesenchymal-like GBM ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Potassium Ion Channels in Malignant Central Nervous System Cancers

        Malignant central nervous system (CNS) cancers are among the most difficult to treat, with low rates of survival and a high likelihood of recurrence. This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. ...

        Research

        Clinical Trials in the Brain Tumour Population: Challenges and Strategies for the Future

        This review identifies challenges and barriers to successful development of drugs in neuro-oncology trials at the preclinical, clinical and translational stages that we believe has contributed to poor outcomes for patients over the last 30 years. ...

        Research

        Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether Ionophore

        Our findings highlight the potential of salinomycin to induce DNA lesions and inhibit homologous recombination to greatly enhance the effect of radiotherapy ...

        Research

        Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams

        While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        A novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Fine mapping under linkage peaks for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil

        The transforming growth factor-beta pathway is important in the immunopathogenesis of Visceral leishmaniasis ...

        Research

        We examined the impact of introducing a dedicated team to OPAT, to define the role of increased medical oversight in improving patient outcomes in this cohort.

        To evaluate the risk of stillbirth, PTB, and SGA as a proxy for FGR following exposure to one or more of these factors in a previous birth. ...

        Research

        Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

        Here, we demonstrate that group A Streptococcus (GAS) utilises Mn(II) import via MtsABC during conditions of hydrogen peroxide stress ...

        Research

        Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study

        We aim to assess the impact of interpregnancy intervals on maternal and child health outcomes in high-income countries ...

        Research

        Developmental respiratory physiology

        Various developmental aspects of respiratory physiology put infants and young children at an increased risk of respiratory failure, which is associated with a higher rate of critical incidents during anesthesia. ...

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