Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Wearable technologies impact upon sexual activity and this influences the decision to adopt the technology ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

We found that BCG, in a mouse model of neonatal polymicrobial sepsis, induced granulocyte colony-stimulating factor (G-CSF) within hours of administration ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Malignant central nervous system (CNS) cancers are among the most difficult to treat, with low rates of survival and a high likelihood of recurrence. This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Visceral leishmaniasis (VL; Leishmania donovani) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10, a cytokine implicated in VL, on this response. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• March 2017

Chronic inflammation may expand sub-populations of T cells expressing CTLA-4 in COPD patients and therefore impair T-cell function ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• June 2017

Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Liquor store availability in early adolescence may be a risk factor for alcohol intake in early and middle, but not late, adolescence ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

The association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012