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        Exposure to household painting and floor treatments, and parental occupational paint exposure and risk of childhood brain tumors

        This study investigated whether household exposure to paints and floor treatments and parental occupational painting were associated with CBT risk... ...

        Research

        Social Gradients in Indigenous Health

        The pattern of association between socioeconomic factors and health outcomes has primarily depicted better health for those who are higher in the social... ...

        Research

        Exciting new clinical trials in cystic fibrosis: Infants need not apply

        The recent announcement of the negative results of the TIGER- 2 phase 3 study of denufosol tetrasodium ...

        Research

        Identification and genetic determination of an early life risk disposition for depressive disorder:

        Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders ...

        Research

        International trends of Down syndrome 1993-2004: Births in relation to maternal age and terminations of pregnancies

        The aim of this study was to examine trends of Down syndrome (DS) in relation to maternal age and termination of pregnancies (ToP) in 20 registries ...

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        Substrate-dependent metabolomic signatures of myeloperoxidase activity in airway epithelial cells: Implications for early cystic fibrosis lung disease

        Myeloperoxidase is released by neutrophils in inflamed tissues. MPO oxidizes chloride, bromide, and thiocyanate to produce hypochlorous acid, hypobromous acid, and hypothiocyanous acid, respectively. These oxidants are toxic to pathogens, but may also react with host cells to elicit biological activity and potential toxicity. In cystic fibrosis and related diseases, increased neutrophil inflammation leads to increased airway MPO and airway epithelial cell exposure to its oxidants. ...

        Research

        Emerging Directions and New Challenges

        In this chapter we provide a brief summary of the key themes of the book, identify emerging directions and challenges in life course theory and data designs and highlight some policy challenges for researchers going forward. © 2022, The Author(s). ...

        Research

        ‘Stranger danger’, ‘abduction risks’ and ‘fear’: Media coverage of children's independent mobility and parental attitudes

        The media plays a powerful role in shaping health-related attitudes and behaviours. We investigated media reports about children's independent mobility (CIM) and associations with parental attitudes towards CIM. CIM-related media reports (newspaper, online, television) during a 3-month period were extracted from two databases. ...

        Research

        The influence of the neighborhood physical environment on early child health and development: A review and call for research

        This review examines evidence of the association between the neighborhood built environment, green spaces and outdoor home area, and early (0-7 years) child... ...

        Research

        Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in

        There is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced malignant pleural mesothelioma. ...

        Research

        Universal child health and early education service use from birth through Kindergarten and developmental vulnerability in the Preparatory Year (age 5 years) in Tasmania, Australia

        This study investigated patterns of universal health and education service use from birth through Kindergarten (age 4 years) and estimated associations between cumulative risk and service use patterns, and between service use patterns and children's developmental vulnerability in the Preparatory Year (age 5 years). ...

        Research

        “We don’t want you to come in and make a decision for us”: Traversing cultural authority and responsive regulation in Australian child protection systems

        The Ngulluk Koolunga Ngulluk Koort (Our Children Our Heart) project conducted extensive Elder and community consultation to develop principles and practice recommendations for child protection governance in Western Australia. We explore these principles and practice recommendations and highlight the need for culturally safe community consultation and governance with a focus on repairing damage incurred by the Aboriginal and Torres Strait Islander community from past child protection policies. ...

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