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        In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma

        Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients. ...

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        Reach and perceived effectiveness of a community-led active outreach postvention intervention for people bereaved by suicide

        Postvention is a core component of suicide prevention strategies, internationally. However, the types of supports provided to people impacted by suicide vary widely. This study examines the perceived effectiveness of the Primary Care Navigator (PCN) model for people bereaved by suicide. The PCN model was implemented in response to a suicide cluster. ...

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        The Relationship Between Traditional and Cyber Bullying Victimization in Early Adolescence and Emotional Wellbeing: A Cross-Sectional, Population-Based Study

        Despite the wealth of knowledge about the impact of bullying victimization, information gaps exist about how traditional and cyber bullying in early adolescence is associated with emotional wellbeing, namely, indicators of positive wellbeing. ...

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        Systematic Review and Meta-analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems

        Irritability is a transdiagnostic indicator of child and adolescent internalizing and externalizing problems that is measurable from early life. The objective of this systematic review was to determine the strength of the association between irritability measured from 0 to 5 years and later internalizing and externalizing problems, to identify mediators and moderators of these relationships, and to explore whether the strength of the association varied according to irritability operationalization. ...

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        Risk factors for dysfunctional grief and functional impairment for all causes of death during the COVID-19 pandemic: The mediating role of meaning

        The COVID-19 pandemic, coupled with significant social changes due to legislative and public health requirements, has changed the way in which people experience grief. We examined whether dysfunctional grief symptoms, disrupted meaning, risk factors, and functional impairment differed between people bereaved from COVID-19 and from other natural or violent causes in this same period. ...

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        Composition of early life leukocyte populations in preterm infants with and without late-onset sepsis

        Composition of leukocyte populations in the first month of life remains incompletely characterised, particularly in preterm infants who go on to develop late-onset sepsis (LOS). The aim of the study was to characterise and compare leukocyte populations in preterm infants with and without LOS during the first month of life. ...

        Research

        Temporally restricted activation of IFNβ signaling determines response to immune checkpoint therapy

        The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

        Research

        Targeting cross-presentation as a route to improve the efficiency of peptide-based cancer vaccines

        Cross-presenting dendritic cells (DC) offer an attractive target for vaccination due to their unique ability to process exogenous antigens for presentation on MHC class I molecules. Recent reports have established that these DC express unique surface receptors and play a critical role in the initiation of anti-tumor immunity, opening the way for the development of vaccination strategies specifically targeting these cells. ...

        Research

        Geospatial modelling for malaria risk stratification and intervention targeting for high burden high impact countries

        Ewan Mark Punam Susan Tasmin Cameron Connell Amratia Rumisha Symons EC MC PA SR TS BSc PhD MSc PhD PhD (Biostatistics) Director of Malaria Risk Stratification Research Assistant, Epidemiology Statistics Honorary Research Associate Honorary Research ...

        Research

        How healthy (or unhealthy) is the food environment around Perth schools?

        Gina Hayley Heather Matt Trapp Christian Croll Cooper GT HC HC MC BHSc(Hons1A), RPHNutr, PhD BSc (1st Class Hons), PhD W.Aust. BHSc BCA Marketing, BSc Statistics and Applied Statistics, PhD ARC DECRA Fellow & Head of Food and Nutrition Research ...

        Research

        Impact for Tourette’s

        Melissa Gail Jenny Andrew Licari Alvares Downs Whitehouse Watch and listen to Andrew ML GA JA AJ PhD PhD BApplSci (physio) MSc PhD PhD Senior Research Fellow Senior Research Fellow Program Head, Development and Disability Angela Wright Bennett ...

        Research

        Infant and Early Childhood Sleep

        Amy Keerthi Jenny Daniel Finlay-Jones Kottampally Downs Ta AFJ KK JA DT BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) Bsc (Hons), GradDipPsych(Adv) BApplSci (physio) MSc PhD BBiomedSc (Hons) Head, Early Neurodevelopment & Mental ...

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