Benefits of physical activity are well recognized for youth with type 1 diabetes mellitus (T1DM), but being active is challenging. In this study, we aimed to investigate the challenges experienced by adolescents, their parents and young adults with T1DM when they are physically active. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Brown adipose tissue (BAT) may be an important metabolic regulator of whole-body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high-fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)-which give rise to DCs-in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low-dose ultraviolet radiation (UVR) significantly reduced the 'whitening' effect of eating a high-fat diet upon interscapular (i) BAT of mice. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

The aim is to identify novel associations between fT3, fT4, and TSH and differentially methylated positions (DMPs) in the genome in subjects from 2 Australian cohorts. We performed an epigenome-wide association study (EWAS) of thyroid function parameters and DNAm using participants from Brisbane Systems Genetics Study and the Raine Study. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

This retrospective population‐based study aimed to determine the incidence of type 2 diabetes from 2012 to 2019 in Western Australian youth aged under 16 years, and to examine temporal trends between 2000 and 2019, using data from the Western Australian Children’s Diabetes Database (WACDD). The data extracted for eligible patients diagnosed with type 2 diabetes, according to standard criteria, included diagnosis year, age, sex and self‐reported Aboriginal or Torres Strait Islander status. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Benefits of physical activity are well recognized for youth with type 1 diabetes mellitus (T1DM), but being active is challenging. In this study, we aimed to investigate the challenges experienced by adolescents, their parents and young adults with T1DM when they are physically active. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

Neuromuscular disorders, chronic diseases and low motor competence have a strong correlation to bone health for appendicular bone parameters in youth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

We aimed to describe the characteristics of Western Australian children aged less than 10 years diagnosed with type 2 diabetes between June 2000 and June 2017 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

A lifestyle intervention starting in the first-trimester pregnancy utilising e-health mode of delivery is feasible ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Our results indicate that pump therapy is associated with a better lipid profile ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

HLA-DQ typing is not cost effective as a first-line screening test for CD in T1D patients because of over-representation of CD permissive HLA alleles in this group ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Findings provide novel insight into the composition of the gut virome during pregnancy and demonstrate a distinct profile of viruses in women with type 1 diabetes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

These findings provide novel insight into the composition of the gut virome during pregnancy and demonstrate a distinct profile of viruses in women with T1D ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019