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        Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia

        PEGasparaginase is known to be a critical drug for treating pediatric acute lymphoblastic leukemia (ALL), however, there is insufficient evidence to determine the optimal dose for infants who are less than one year of age at diagnosis. This international study was conducted to identify the pharmacokinetics of PEGasparaginase in infants with newly diagnosed ALL and gather insight into the clearance and dosing of this population. ...

        Research

        Azithromycin reduces bronchial wall thickening in infants with cystic fibrosis

        COMBAT-CF showed that children aged 0-3 years treated with azithromycin did clinically better than placebo but there was no effect on CT-scores. We reanalysed CTs using an automatic bronchus-artery (BA) analysis. ...

        Research

        Assessing emotion beliefs with the Polish version of the Emotion Beliefs Questionnaire (EBQ): psychometric properties, norms, and links with emotional reactivity and psychopathology

        Originally developed in English, the Emotion Beliefs Questionnaire (EBQ) is a self-report measure of beliefs about the controllability and usefulness of negative and positive emotions. In this study, we introduce the Polish version and examine its psychometric properties and links with emotional outcomes. Our sample was 914 Polish adults aged 18–70 from the general population.  ...

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        Germ-line and somatic DICER1 mutations in pineoblastoma

        This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

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        Early infant feeding and adiposity risk: from infancy to adulthood

        In our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as... ...

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        Contact with the juvenile justice system in children treated with stimulant medication for attention deficit hyperactivity disorder

        We aimed to investigate juvenile justice encounters in children with and without ADHD. ...

        Research

        The safety of seasonal influenza vaccines in Australian children in 2013

        Our objective was to examine influenza vaccine safety in Australian children aged under 10 years in 2013. ...

        Research

        A pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemia

        Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. ...

        Research

        DataSHIELD: taking the analysis to the data, not the data to the analysis

        DataSHIELD provides a novel technological solution that can facilitate the access of researchers and other healthcare professionals to individual-level data ...

        Research

        Understanding food security issues in remote Western Australian Indigenous communities

        This study explored food insecurity in remote Western Australian (WA) Indigenous communities in a survey of remote community store managers' views. ...

        Research

        Target validation of the inosine monophosphate dehydrogenase (IMPDH) gene in Cryptosporidium using Phylomer® peptides

        Cryptosporidiosis, a gastroenteric disease characterised mainly by diarrheal illnesses in humans and mammals is caused by infection with the protozoan... ...

        Research

        Will Global Climate Change Alter Fundamental Human Immune Reactivity: Implications for Child Health?

        We postulate several mechanisms whereby climate change sensitive exposures and conditions will subtly impair aspects of the human immune response ...

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