Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has given rise to unique and idiosyncratic features of the mtDNA and its expression machinery that can be specific to different organisms. In animals, the mitochondrial protein synthesis machinery has acquired many new components and mechanisms over evolution. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

The evolutionary acquisition of mitochondria has given rise to the diversity of eukaryotic life. Mitochondria have retained their ancestral α-proteobacterial traits through the maintenance of double membranes and their own circular genome. Their genome varies in size from very large in plants to the smallest in animals and their parasites. The mitochondrial genome encodes essential genes for protein synthesis and has to coordinate its expression with the nuclear genome from which it sources most of the proteins required for mitochondrial biogenesis and function. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Growing evidence supports a role for infection in the etiology of ALL and the involvement of immune systems suggests that vaccination may also play a role. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

We assessed replication and excretion of the live attenuated CYD-TDV into biological fluids following vaccination in dengue-naive adults in Australia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

The predominant occurrence of extragonadal teratomas/teratocarcinomas in human neonates suggests that pluripotent cells are tumour-forming even during... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• October 2015

Higher levels of paternal dietary vitamin B12 were appeared to be associated with an increased risk of childhood ALL, with those in the highest tertile of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

Expert assessment is often used to assess lifetime occupational exposures, but these assessments generally lack transparency and are very time-consuming. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• November 2013

The evidence that accelerated fetal growth is associated with a modest increased risk of childhood ALL is strong and consistent with known biological... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• June 2013

Increased risks were observed for maternal exposure to diesel exhaust any time before the child's birth and paternal exposure around the time of the child's... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• June 2013

It is unknown whether parental occupational exposure to chemicals before during and after pregnancy increases the risk of acute lymphoblastic... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• November 2011

The relation between intrauterine growth and risk of childhood acute lymphoblastic leukemia was investigated in an Australian population-based case-control... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• April 2009