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        253-264 of 785 results for 'asthma'

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        Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

        GWAS analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis suggested shared genetic mechanisms across rhinitis-related traits ...

        Research

        Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

        Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels. ...

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        Allergen ligands in the initiation of allergic sensitization topical collection on allergens

        Many important allergens are not covalently bound to lipid or carbohydrate, but have structures belonging to lipid, glycan and glycolipid-binding families. ...

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        Exacerbation of chronic cigarette-smoke induced lung disease by rhinovirus in mice

        A significant proportion of chronic obstructive pulmonary disease exacerbations are strongly associated with rhinovirus infection (HRV). In this study, we combined long-term cigarette smoke exposure with HRV infection in a mouse model. ...

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        European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

        Atopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date combining previously reported cohorts with additional available data. ...

        Research

        Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

        Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG on the development of early‐onset atopic dermatitis ...

        Research

        Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

        Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. ...

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        Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

        Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic... ...

        Research

        Vitamin D supplementation, moderate sun exposure, and control of immune diseases

        There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. ...

        Research

        Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

        Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. ...

        Research

        IgE and IgG binding patterns and T-cell recognition of fel d 1 and Non-Fel d 1 cat allergens

        To compare IgE and IgG antibody binding and T-cell recognition of the major cat allergen Fel d 1 with other cat proteins with known IgE binding properties. ...

        Research

        Insights into respiratory disease through bioinformatics

        Here, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases ...

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