Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• September 2011

RNA-sequencing (RNA-seq) efforts in acute lymphoblastic leukaemia have identified numerous prognostically significant genomic alterations which can guide diagnostic risk stratification and treatment choices when detected early. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

Unlike adults, malignant melanoma in children and adolescents is rare. In adult melanoma, significant progress in understanding tumor biology and new treatments, including targeted therapies and immunotherapy have markedly improved overall survival. In sharp contrast, there is a paucity of data on the biology and clinical behavior of pediatric melanoma. We report a national case series of all pediatric and adolescent malignant melanoma presenting to ANZCHOG Childhood Cancer Centers in Australia and New Zealand. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

This JAK3A572V knockin model is a relevant new tool for testing the efficacy of JAK inhibitors in JAK3-related hematopoietic malignancies ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Despite initial improvements in survival of infants with ALL since establishment of the first pediatric cooperative group ALL trials, the poor outcome has... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• April 2014

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

We provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018