Alison Linda W. Joost Omar McDonnell Wijaya Lesterhuis Elaskalani AM LW WJL OE BSc (Hons), PhD BSc PhD BSc, MSc, PhD Early Career Fellow Postdoctoral Researcher Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head Senior Research ...

• 1. Telethon Kids Institute
• Projects

Non-Aspergillus molds and non-albicans Candida contributed substantially to pediatric invasive fungal infection in our study ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

This Australia-wide study examines whether maternal intake of folate and vitamins B6 and B12 during pregnancy is associated with development of brain tumors... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• June 2014

Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

The aim of our study was to investigate whether CBL0137 has potential as a therapeutic and chemopotentiating compound in MLL-r leukemia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

In this study, we report the case of an adolescent NMC patient presenting with severe facial pain, proptosis and visual impairment due to a mass arising from... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Delivering cancer control at scale for Aboriginal and Torres Strait Islander communities is a national priority that requires Aboriginal and Torres Strait Islander leadership and codesign, as well as significant involvement of the Aboriginal community-controlled health sector. The unique genomic variation observed among Aboriginal and Torres Strait Islander peoples may have implications for standard and precision medicine. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024