Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Irritability is a transdiagnostic indicator of child and adolescent internalizing and externalizing problems that is measurable from early life. The objective of this systematic review was to determine the strength of the association between irritability measured from 0 to 5 years and later internalizing and externalizing problems, to identify mediators and moderators of these relationships, and to explore whether the strength of the association varied according to irritability operationalization. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Cross-presenting dendritic cells (DC) offer an attractive target for vaccination due to their unique ability to process exogenous antigens for presentation on MHC class I molecules. Recent reports have established that these DC express unique surface receptors and play a critical role in the initiation of anti-tumor immunity, opening the way for the development of vaccination strategies specifically targeting these cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

Nick Gottardo NG MBChB FRACP PhD Co-Head, Brain Tumour Research nicholas.gottardo@telethonkids.org.au Co-Head, Brain Tumour Research Professor Nick Gottardo co-leads the Brain Tumour Research Programme at the Telethon Kids Institute. He is also Head ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Composition of leukocyte populations in the first month of life remains incompletely characterised, particularly in preterm infants who go on to develop late-onset sepsis (LOS). The aim of the study was to characterise and compare leukocyte populations in preterm infants with and without LOS during the first month of life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

This report regards the health & wellbeing of Australian children & adolescents. Based on a survey conducted in the homes of over 6,300 families with... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Interleukin-10 is a key immunomodulatory cytokine the principal function of which is to limit the magnitude of immune response. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• March 2011

To establish baseline prevalence of neural tube defects (NTDs) prior to mandatory folic acid fortification in Australia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• August 2010

Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• June 2010

This article discusses the rising prevalence of pertussis disease in countries which have switched to acellular vaccines. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

The purpose of this article is to investigate whether the number and timing of stressors experienced during pregnancy impacted longterm motor development at... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• October 2015