The abundance of cell-free microRNA (miRNA) has been measured in blood plasma and proposed as a source of novel, minimally invasive biomarkers for several diseases. Despite improvements in quantification methods, there is no consensus regarding how haemolysis affects plasma miRNA content. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Acute lymphoblastic leukemia and childhood brain tumors are 2 of the most common forms of childhood cancer, but little is known of their etiology. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

We identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Advancements in genomic profiling led to the discovery of four major molecular subgroups in medulloblastoma (MB), which have now been incorporated into the World Health Organization classification of central nervous system tumors. The current study aimed to determine the prognostic significance of the MB molecular subgroups among children in Malaysia.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021