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        265-276 of 418 results for 'END RHD'

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        Harmonizing Surveillance Methodologies for Group A Streptococcal Diseases

        Group A Streptococcus (Strep A) is responsible for a significant global health and economic burden. The recent prioritization of Strep A vaccine development by the World Health Organization has prompted global research activities and collaborations. To progress this prioritization, establishment of robust surveillance for Strep A to generate updated regional disease burden estimates and to establish platforms for future impact evaluation is essential. ...

        Research

        Hospital use in Aboriginal and non-Aboriginal patients with chronic disease

        Aboriginal people use health services in a different manner when compared to non-Aboriginal people ...

        Research

        Management of invasive group A streptococcal infections

        Invasive group A streptococcal disease in children includes deep soft tissue infection, bacteraemia, bacteraemic pneumonia, meningitis and osteomyelitis ...

        Research

        Evaluation of safety and immunogenicity of a group a streptococcus vaccine candidate (mj8vax) in a randomized clinical trial

        Intramuscular administration of novel acetylated peptide-protein conjugate vaccine candidate MJ8VAX was demonstrated to be safe and immunogenic ...

        Research

        An economic case for a vaccine to prevent group A streptococcus skin infections

        A vaccine that prevents GAS cellulitis and other skin infections, in addition to throat infections, would maximise its value and commercial viability ...

        Research

        Development of an opsonophagocytic killing assay for group a streptococcus

        This Group A Streptococcus OPKA assay has the potential to provide a robust and reproducible platform to accelerate GAS vaccine development ...

        Research

        Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

        We review the Group A Streptococcus Human infection studies and present the study protocol for a dose-ranging inpatient study in healthy adults ...

        Research

        Rheumatic heart disease in pregnancy: How can health services adapt to the needs of Indigenous women? A qualitative study

        Health systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease ...

        Research

        Primary prevention of rheumatic fever in the 21st century: evaluation of a national programme

        Population-based primary prevention of ARF through sore throat management may be effective in well-resourced settings like New Zealand ...

        Research

        Extensive Diversity of Streptococcus pyogenes in a Remote Human Population Reflects Global-Scale Transmission Rather than Localised Diversification

        The Indigenous population of the Northern Territory of Australia (NT) suffers from a very high burden of Streptococcus pyogenes disease, including cardiac... ...

        Research

        Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

        Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. ...

        Research

        Standardization of Epidemiological Surveillance of Acute Poststreptococcal Glomerulonephritis

        Acute poststreptococcal glomerulonephritis (APSGN) is an immune complex-induced glomerulonephritis that develops as a sequela of streptococcal infections. This article provides guidelines for the surveillance of APSGN due to group A Streptococcus (Strep A). The primary objectives of APSGN surveillance are to monitor trends in age- and sex-specific incidence, describe the demographic and clinical characteristics of patients with APSGN, document accompanying risk factors, then monitor trends in frequency of complications, illness duration, hospitalization rates, and mortality. ...

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