We identified several novel candidate genes which warrant further analysis in cohorts matched more precisely for clinical phenotypes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Reviewed in this article these studies have identified positive association at 21 genes with association at five of these replicated in independent populations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• March 2012

The transforming growth factor-beta pathway is important in the immunopathogenesis of Visceral leishmaniasis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• July 2010

Here we employ whole blood assays to evaluate human cytokine responses to 11 of these antigens, in comparison to known defined and crude antigen preparations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacte ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• June 2010

These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• May 2016

There is a high incidence of vaccine-preventable morbidity post-allogeneic haematopoietic stem cell transplantation in West Australian children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Post kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

Findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%. In total, 83% (n = 20/24) proceeded to haematopoietic stem cell transplant, directly after blinatumomab (n = 12) or following additional salvage therapy (n = 8). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

Influenza infection contributes substantially to global morbidity and mortality, with children undergoing treatment for cancer among the most vulnerable due to immunosuppression associated with disease and treatment. However, influenza remains one of the most common vaccine-preventable diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023