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        265-276 of 785 results for 'asthma'

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        Infant respiratory infections and later respiratory hospitalisation in childhood

        The aim of this study was to use total-population based data on an otherwise healthy population of children to assess the relationship between early... ...

        Research

        Analysis of IgE binding patterns to house dust mite allergens in scabies-endemic communities: insights for both diseases

        This study analysed the IgE binding patterns caused by house dust mite allergens in scabies endemic communities in Australia. ...

        Research

        Mechanisms of IgE sensitization

        Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

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        Transcription factor p63 regulates key genes and wound repair in human airway epithelial Basal cells

        The airway epithelium in asthma displays altered repair and incomplete barrier formation. ...

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        Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae

        The aim of this study was to identify features of innate, cell-mediated and humoral immunity that may increase susceptibility to respiratory infections in... ...

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        Variants associated with HHIP expression have sexdifferential effects on lung function

        Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. ...

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        An exposome perspective: Early-life events and immune development in a changing world

        Here we review the historical origins of exposome research and define a new concept, the metaexposome ...

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        Lung function changes in children exposed to mine fire smoke in infancy

        Chronic, low-intensity air pollution exposure has been consistently associated with reduced lung function throughout childhood. However, there is limited research regarding the implications of acute, high-intensity air pollution exposure. We aimed to determine whether there were any associations between early life exposure to such an episode and lung growth trajectories. ...

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        Time spent outdoors through childhood and adolescence - assessed by 25-hydroxyvitamin D concentration - and risk of myopia at 20 years

        To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. Participants of the Raine Study Generation 2 cohort had 25(OH)D concentrations measured at the 6-, 14-, 17- and 20-year follow-ups. Participants underwent cycloplegic autorefraction at age 20 years, and myopia was defined as a mean spherical equivalent -0.50 dioptres or more myopic. Logistic regression was used to analyse the association between risk of myopia at age 20 years and age-specific 25(OH)D concentrations. Linear mixed-effects models were used to analyse trajectory of 25(OH)D concentrations from 6 to 20 years. ...

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        Mechanical Abnormalities of the Airway Wall in Adult Mice After Intrauterine Growth Restriction

        We propose that mechanical abnormalities of the airway wall acquired through disrupted fetal growth impact susceptibility to disease ...

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        Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.

        The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric ARI. ...

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        Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction

        The rat model demonstrates that intrauterine growth restriction leads to a more heterogeneous distribution of airway lumen calibre in adulthood ...

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