Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

Advancements in genomic profiling led to the discovery of four major molecular subgroups in medulloblastoma (MB), which have now been incorporated into the World Health Organization classification of central nervous system tumors. The current study aimed to determine the prognostic significance of the MB molecular subgroups among children in Malaysia.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

We identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Bevacizumab is well tolerated and appears most effective for rapid tumor control to preserve vision and improve morbidity ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

This chapter summarizes recent advances in diffuse intrinsic pontine glioma and potential novel therapies ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

In this study, we report the case of an adolescent NMC patient presenting with severe facial pain, proptosis and visual impairment due to a mass arising from... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

Here we describe 19 new cases with RASopathy due to disease-causing variants in NRAS ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• June 2017

Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

The abundance of cell-free microRNA (miRNA) has been measured in blood plasma and proposed as a source of novel, minimally invasive biomarkers for several diseases. Despite improvements in quantification methods, there is no consensus regarding how haemolysis affects plasma miRNA content. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

ZFTA-RELA (formerly known as c11orf-RELA) fused supratentorial ependymoma has been recognized as a novel entity in the 2016 WHO classification of CNS tumors and further defined in the recent 2021 edition. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023