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        High burden of infectious disease and antibiotic use in early life in Australian Aboriginal communities

        Early life infections drive high antibiotic prescribing rates in remote Aboriginal communities ...

        Research

        Safety and immunogenicity of pneumococcal conjugate vaccines in a high-risk population: a randomised controlled trial of PCV in Papua New Guinean infants

        Infant vaccination with 3 doses of PCV10 or PCV13 is safe and immunogenic in a highly endemic setting ...

        Research

        Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

        Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life ...

        Research

        Determinants for progression from asymptomatic infection to symptomatic visceral leishmaniasis: A cohort study

        We confirmed the strong association between high DAT and/or rK39 titers and progression to disease among asymptomatic subjects ...

        Research

        Influenza Epidemiology, Vaccine Coverage and Vaccine Effectiveness in Children Admitted to Sentinel Australian Hospitals in 2017

        Significant influenza-associated morbidity was observed in 2017 in Australia. Vaccine coverage and antiviral use was inadequate. ...

        Research

        Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

        Children of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, whereas asthma may follow a different pattern ...

        Research

        Trends and predictors of extreme preterm birth: Western Australian population-based cohort study

        First study to show that the increase in extreme preterm birth in high-income jurisdiction is no longer evident after medical terminations and birth defects are excluded ...

        Research

        Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing

        Asthma exacerbations in children can be divided into IRF7hi versus IRF7lo phenotypes with associated differences in clinical phenotypes ...

        Research

        Antibody persistence and booster response in adolescents and young adults 4 and 7.5 years after immunization with 4CMenB vaccine

        A more robust immune response after booster compared to a first dose in vaccine-naïve individuals, showed effective priming in an adolescent/young adult population ...

        Research

        Time to tackle rheumatic heart disease: Data needed to drive global policy dialogues

        This report provides an update on the contemporary global and regional policy landscapes relevant to rheumatic heart disease ...

        Research

        Potential for molecular testing for group a streptococcus to improve diagnosis and management in a high-risk population: A prospective study

        Implementation of molecular testing could improve antibiotic use in this high-burden setting ...

        Research

        Parent-observed thematic data on quality of life in children with autism spectrum disorder

        Parent observations provide an initial framework for understanding quality of life in autism spectrum disorder ...

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