To identify links between drug resistance and gene deregulation we used oligonucleotide microarray technology. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• March 2012

Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Unlike adults, malignant melanoma in children and adolescents is rare. In adult melanoma, significant progress in understanding tumor biology and new treatments, including targeted therapies and immunotherapy have markedly improved overall survival. In sharp contrast, there is a paucity of data on the biology and clinical behavior of pediatric melanoma. We report a national case series of all pediatric and adolescent malignant melanoma presenting to ANZCHOG Childhood Cancer Centers in Australia and New Zealand. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

RNA-sequencing (RNA-seq) efforts in acute lymphoblastic leukaemia have identified numerous prognostically significant genomic alterations which can guide diagnostic risk stratification and treatment choices when detected early. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

We report a term male with congenital acute erythroleukemia who achieved sustained remission with low-dose cytosine arabinoside alone ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Bevacizumab is well tolerated and appears most effective for rapid tumor control to preserve vision and improve morbidity ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

This chapter summarizes recent advances in diffuse intrinsic pontine glioma and potential novel therapies ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

In this study, we report the case of an adolescent NMC patient presenting with severe facial pain, proptosis and visual impairment due to a mass arising from... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

Omar Merridee Sébastien Laurence Rishi Sury Terrance Timo Raelene W. Joost Elaskalani Wouters Malinge Cheung Kotecha Johns Lassmann Endersby Lesterhuis OE MW SM LC RS T T R WJL BSc, MSc, PhD Bsc Hons (Physics), PhD PhD BPharm (Hons) MBA PhD MB ChB ( ...

• Telethon Kids Institute
• Projects

We provide new evidence to support current guidelines for orchidopexy before age 18 months to decrease the risk of future testicular cancer and infertility ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018