Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection (involving more than one micro-organism) of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Antibiotics are the most common treatment for CSOM, which act to kill or inhibit the growth of micro-organisms that may be responsible for the infection. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

The functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

Valerie Verhasselt VV MD, PhD Head, Immunology and Breastfeeding 0402997617 Valerie.verhasselt@telethonkids.org.au Head, Immunology and Breastfeeding @valerieverhass1 Professor Verhasselt is Head of Immunology and Breast Feeding at the Telethon ...

• Telethon Kids Institute
• Projects

Mucopolysaccharidosis type IIIA (MPS IIIA) is characterized by neurological and skeletal pathologies caused by reduced activity of the lysosomal hydrolase, sulfamidase, and the subsequent primary accumulation of undegraded heparan sulfate (HS). Respiratory pathology is considered secondary in MPS IIIA and the mechanisms are not well understood.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

Electronic cigarettes (e-cigarettes) are often perceived to be safer than smoking, which has led to some women switching to e-cigarettes during pregnancy. However, the effects of switching from smoking to e-cigarettes on both pregnancy outcomes and the foetus are largely unknown. This study aimed to investigate the effects of switching from tobacco smoking to e-cigarette use in very early pregnancy on birth outcomes, neurodevelopment and behaviour of the offspring. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Increased fracture incidence in Western Australia between 2005 and 2015 identifies a concerning trend for bone health in children and adolescents ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

This is the third fact sheet regarding the Aboriginal and Torres Strait Islander Suicide Prevention Evaluation Project. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Our team: Karen Forde (Project Lead), Candice Rainsford (Project Coordinator), Aida Noordin (Research Assistant) and Joanne Readman (Project Assistant). External collaborators: Ken Resnicow (University of Michigan), James White (Reach HPI) Partners: ...

• Telethon Kids Institute
• Projects

Our results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

Findings from this study provide empirical evidence for the heterogeneity of sleep problems and their development ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

The purpose of this study was to describe qualitatively the experience of parenting for mothers of a child with Down syndrome. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• March 2012