T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed at a young age. Patients are treated with intensive chemotherapy, potentially followed by a hematopoietic stem cell transplantation. Although prognosis of T-LBL has improved with intensified treatment protocols, they are associated with side effects and 10-20% of patients still die from relapsed or refractory disease. Given this, the search toward less toxic anti-lymphoma therapies is ongoing. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

This study describes the development and molecular characterization of a panel of patient-derived infant leukemia oncogene xenografts and their sensitivity... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4+ T cell responses and their regulation by major histocompatibility complex class II (MHC II) in the skin. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Bevacizumab is well tolerated and appears most effective for rapid tumor control to preserve vision and improve morbidity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

This chapter summarizes recent advances in diffuse intrinsic pontine glioma and potential novel therapies ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

In this study, we report the case of an adolescent NMC patient presenting with severe facial pain, proptosis and visual impairment due to a mass arising from... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

Omar Merridee Sébastien Laurence Rishi Sury Terrance Timo Raelene W. Joost Elaskalani Wouters Malinge Cheung Kotecha Johns Lassmann Endersby Lesterhuis OE MW SM LC RS T T R WJL BSc, MSc, PhD Bsc Hons (Physics), PhD PhD BPharm (Hons) MBA PhD MB ChB ( ...

• 1. Telethon Kids Institute
• Projects

We provide new evidence to support current guidelines for orchidopexy before age 18 months to decrease the risk of future testicular cancer and infertility ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

We demonstrated the efficacy of FPPa-OmoMYC in inhibiting breast cancer growth when injected orthotopically in TNBC allografts ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

One of the great success stories of modern medicine is undoubtedly the remarkable improvement in outcome for childhood cancer, achieved through the work of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015