We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Despite initial improvements in survival of infants with ALL since establishment of the first pediatric cooperative group ALL trials, the poor outcome has... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• April 2014

We provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Advancements in genomic profiling led to the discovery of four major molecular subgroups in medulloblastoma (MB), which have now been incorporated into the World Health Organization classification of central nervous system tumors. The current study aimed to determine the prognostic significance of the MB molecular subgroups among children in Malaysia.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

We identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• July 2012

Our data emphasize the heterogeneity of NMC and highlights genetic aberrations that could be explored to improve therapeutic strategies. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• December 2017

Untreated hepatitis C virus (HCV) infection can result in cirrhosis and hepatocellular cancer. Direct-acting antiviral (DAA) therapies are highly effective and have few side effects compared to older interferon-based therapy. Despite the Australian government providing subsidised and unrestricted access to DAA therapy for chronic HCV infection, uptake has not been sufficient to meet the global target of eliminating HCV as a public health threat by 2030.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

The strongest determinants of self-reported sun-protection behavior changes due to concerns about vitamin D were attitudes and location ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed at a young age. Patients are treated with intensive chemotherapy, potentially followed by a hematopoietic stem cell transplantation. Although prognosis of T-LBL has improved with intensified treatment protocols, they are associated with side effects and 10-20% of patients still die from relapsed or refractory disease. Given this, the search toward less toxic anti-lymphoma therapies is ongoing. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023