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        277-288 of 666 results for 'early lung health'

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        Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement

        Standards and consensus recommendations are presented for manufacturers, clinicians, operators, and researchers ...

        Research

        End-inspiratory molar mass step correction for analysis of infant multiple breath washout tests

        We aimed to evaluate the use of the EIMM-step method in a broad range of infants. ...

        Research

        Clinical investigation of respiratory system admittance in preschool children

        We compared the ability of Ars, to standard oscillatory outcomes, to determine respiratory disease and differentiate responses to inhaled bronchial challenges. ...

        Research

        Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells

        Apically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces. ...

        Research

        Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

        Maintaining sufficient vitamin D is necessary for optimal lung health, and vitamin D may modulate the lung microbiome in a sex-specific fashion ...

        Research

        A phase I clinical trial assessing the safety, tolerability, and pharmacokinetics of inhaled ethanol in humans as a potential treatment for respiratory tract infections

        Current treatments for respiratory infections are severely limited. Ethanol's unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment for respiratory infections if it can be delivered safely to the airway by inhalation. Here, we explore the safety, tolerability, and pharmacokinetics of inhaled ethanol in a phase I clinical trial. ...

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        Computational fluid-particle dynamic and pharmacokinetic assessment of electronic cigarette aerosols for improved understanding of their potential to impact health

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

        Research

        ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma

        COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

        Research

        Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

        The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

        Research

        The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome

        Long-term survival after lung transplantation is hindered by the development of bronchiolitis obliterans syndrome (BOS). ...

        Research

        PRAGMA-CF. A Quantitative Structural Lung Disease Computed Tomography Outcome in Young Children with Cystic Fibrosis

        Chest computed tomography (CT) is the gold standard for demonstrating cystic fibrosis (CF) airway disease. However, there are no standardized outcome... ...

        Research

        Prevalence of chronic wet cough and protracted bacterial bronchitis in aboriginal children

        Strategies to address reasons for and treatment of chronic wet cough and protracted bacterial bronchitis in young Aboriginal children in remote north Western Australia are required ...

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