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        277-288 of 786 results for 'genetic'

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        Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil

        Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. ...

        Research

        Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data

        Here we compare the performance of several LMM approaches (and software implementations, including EMMAX, GenABEL, FaST-LMM, Mendel, GEMMA and MMM) via their... ...

        Research

        Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

        We found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. ...

        Research

        Interleukin 10 gene polymorphisms and development of post kala-azar dermal leishmaniasis in a selected sudanese population

        Post kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment. ...

        Research

        Personalised analytics for rare disease diagnostics

        Here we focus on the problem of prioritising variants with respect to the observed disease phenotype ...

        Research

        Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

        Our data indicate epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex, and likely reflects pathways modified by gene-environment interactions in food allergy ...

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        Does otitis media in early childhood affect later behavioural development? Results from the Western Australian Pregnancy Cohort (Raine) Study

        The relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders. ...

        Research

        Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

        Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and re ...

        Research

        Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism

        We examined the baseline profile of a panel of T-ALL cell lines to determine factors that contribute to GC resistance without prior drug selection. ...

        Research

        Prenatal origins and health outcomes of male reproductive congenital anomalies diagnosed at birth and testicular cancer in adulthood

        Liz Milne E MPH PhD Honorary Emeritus Fellow Honorary Emeritus Fellow Liz is an epidemiologist specialising in the aetiology and prevention of childhood cancers and other chronic diseases. For over a decade, her research has had a strong focus on ...

        Research

        Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection

        Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens. ...

        Research

        Prevention - what is the most promising approach?

        This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma ...

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