While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Laboratory models provide an important tool in helping to understand the cellular and molecular drivers of respiratory disease. Many animal models exist that model the neonatal outcomes of preterm birth. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the disease and the impact of current therapies are limited. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

There is no consensus on how best to measure responses to interventions among children and adults with cystic fibrosis (CF). We have systematically reviewed and summarised the characteristics and measurement properties of tests and tools that have been used to capture outcomes in studies among people with CF, including their reliability, validity and responsiveness. This review is intended to guide researchers when selecting tests or tools for measuring treatment effects in CF trials. A consensus set of these tests and tools could improve consistency in how outcomes are captured and thereby facilitate comparisons and synthesis of evidence across studies. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

Early motor impairments have been reported in children with neurodevelopmental disorders (NDD), but it is not clear if early detection of motor impairments can identify children at risk for NDD or how early such impairments might be detected. Our aim was to characterize early motor function in children later diagnosed with NDD relative to typically developing children or normative data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

A standardised framework for selecting outcomes for evaluation in trials has been proposed by the Core Outcome Measures in Effectiveness Trials working group. However, this method does not specify how to ensure that the outcomes that are selected are causally related to the disease and the health intervention being studied. Causal network diagrams may help researchers identify outcomes that are both clinically meaningful and likely to be causally dependent on the intervention, and endpoints that are, in turn, causally dependent on those outcomes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Children who attended playgroup had better development at school entry relative to those who had not attended playgroup ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Adam Punam Susan Tolu Saddler Amratia Rumisha Okitika AS PA SR TO PhD PhD PhD (Biostatistics) BSc, MPH, PMP Research Officer Honorary Research Associate Honorary Research Associate Senior Program Manager; Deputy Theme Head, Brain and Behaviour ...

• 1. Telethon Kids Institute
• Projects

Keely Leanne Bebbington Fried KB LF MClinPsych/PhD BSc DipEd MSpEd EdD McCusker Postdoctoral Research Fellow in Type 1 Diabetes Senior Research Fellow 08 6319 1766 08 6319 1480 keely.bebbington@telethonkids.org.au Leanne.Fried@telethonkids.org.au ...

• 1. Telethon Kids Institute
• Projects

Yael Penelope Helen Perry Strauss Morgan YP PS HM BPsych (Hons) MPsych (Clin) PhD BA, MPH, PhD BA (Hons), Doctor of Psychology Program Head, Mental Health & Youth; Head, Youth Mental Health Research Fellow in Youth Suicide Prevention Senior Project ...

• 1. Telethon Kids Institute
• Projects

Ellen Yasmin Rosemary Harvey Harman-Smith Cahill EH YHS RC BSocWk(Hons) BA, BHlthSc(Hons), PhD EdD, MEd, BEd(Hons) Senior Project Coordinator Head, Early Years Systems Evidence; Head, Tenders Support Unit Principal Research Fellow (08) 6375 6117 ...

• 1. Telethon Kids Institute
• Projects
• Past projects

Tess Yasmin Neida Gregory Harman-Smith Sechague Monroy TG YHS NSM BSc (Hons), PhD (Psychology) BA, BHlthSc(Hons), PhD BDS, MPH Senior Research Fellow Head, Early Years Systems Evidence; Head, Tenders Support Unit Research Assistant +61 8 6375 6113 ...

• 1. Telethon Kids Institute
• Our research
• Brain and Behaviour
• Population Health Program
• Early Years Systems Evidence