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        Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

        A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator PrfA controls expression of key virulence factors that enable exploitation of this intracellular niche. ...

        Research

        Microbiome and Functional Analysis of a Traditional Food Process: Isolation of a Novel Species (Vibrio hibernica) With Industrial Potential

        Vibrio hibernica is capable of metabolizing a unique carbohydrate profile at low temperatures ...

        Research

        Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency

        We aimed to investigate the molecular basis underlying a novel phenotype including hypopituitarism associated with primary ovarian insufficiency. ...

        Research

        In silico evolution of nucleic acid-binding proteins from a nonfunctional scaffold

        Directed evolution emulates the process of natural selection to produce proteins with improved or altered functions. These approaches have proven to be very powerful but are technically challenging and particularly time and resource intensive. To bypass these limitations, we constructed a system to perform the entire process of directed evolution in silico. ...

        Research

        Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium study

        The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation of the immune system, that is, day-care center... ...

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        Participation in population-based case-control studies: Does the observed decline vary by socio-economic status?

        An Australian study of childhood leukaemia (Aus-ALL) previously reported that control participation was positively associated with socio-economic status... ...

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        Exposure to pesticides and the risk of childhood brain tumors

        This Australian case-control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were... ...

        Research

        Exposure to household painting and floor treatments, and parental occupational paint exposure and risk of childhood brain tumors

        This study investigated whether household exposure to paints and floor treatments and parental occupational painting were associated with CBT risk... ...

        Research

        Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case-control study

        The aim of this analysis was to investigate whether maternal coffee or tea consumption during pregnancy was associated with the risk of CBT. ...

        Research

        Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

        Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic... ...

        Research

        Childhood brain tumours: Associations with parental occupational exposure to solvents

        Paternal exposure to solvents in the year before conception was associated with an increased CBT risk. This increased risk appeared to be mainly attributable... ...

        Research

        Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities

        Reading Disability is often characterized by difficulties in the phonology of the language. While the molecular mechanisms underlying it are largely undetermined, loci are being revealed by genome-wide association studies. ...

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