Alison Linda W. Joost Omar McDonnell Wijaya Lesterhuis Elaskalani AM LW WJL OE BSc (Hons), PhD BSc PhD BSc, MSc, PhD Early Career Fellow Postdoctoral Researcher Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head Senior Research ...

• 1. Telethon Kids Institute
• Projects

Pat Belinda Holt Hales PG BJ PhD, DSc, FRCPath, FRCPI, FAA BSc (Hons) PhD Emeritus Honorary Researcher Senior Manager, Research Platforms Patrick.Holt@telethonkids.org.au belinda.hales@telethonkids.org.au Emeritus Honorary Researcher Senior Manager ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Human Immunology

Advances in medicine have improved the chances of survival following burn injuries, however, psychosocial outcomes have not seen the same improvement, and burn injuries can be distressing for both the child or young person, negatively affecting their wellbeing. Pediatric burn patients are at a higher risk of developing psychopathology compared to the general population. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Despite the medical and surgical improvements of paediatric burn injuries, burn injuries can be a painful and traumatic experience for the child and their family. It is therefore important to explore the experiences of caregivers who support their child throughout the burn journey. Thus, the purpose of this study was to explore the traumatic nature of paediatric burns on the family from a caregiver's perspective. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

The choice of RHD is telling: the disease is a marker of inequality, a novel lens for considering health systems and a feasible target for disease control. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

Children born to parents with intellectual disability (ID) have been shown as disproportionally represented in child protection services however with limited population-based research. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Aboriginal people use health services in a different manner when compared to non-Aboriginal people ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

Since the discovery of MECP2 duplication syndrome (MDS) in 1999, efforts to characterise this disorder have been limited by a lack of large datasets, with small case series often favouring the reporting of certain conditions over others. This study is the largest to date, featuring 134 males and 20 females, ascertained from the international MECP2 Duplication Database (MDBase). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• April 2022

Over 400 million people worldwide are living with a rare disease. Next Generation Sequencing identifies potential disease causative genetic variants. However, many are identified as variants of uncertain significance and require functional laboratory validation to determine pathogenicity, and this creates major diagnostic delays. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Over 5 days, 120 schoolchildren from two schools in the remote Kimberley region of Australia were screened for Strep A pharyngitis. Molecular point-of-care testing identified Strep A pharyngitis in 13/18 (72.2%) symptomatic children. The portability and feasibility of molecular point-of-care testing was highly practical for remote settings. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020