Browse study websites

Discover. Prevent. Cure.

Menu Fundraise Donate

    Recommended pages

      Do you mean

        301-312 of 678 results for 'cancer''

        Refine research

        Research

        Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.

        This study describes the development and molecular characterization of a panel of patient-derived infant leukemia oncogene xenografts and their sensitivity... ...

        Research

        SJ-ELiOT: St Jude - Phase 1 Evaluation of LY2606368, Molecularly-Targeted CHK1/2i Therapy, in Combination with Cyclophosphamide or Gemcitabine for Children and Adolescents with Refractory or Recurrent Medulloblastoma Brain Tumours

        Nick Raelene Gottardo Endersby NG R MBChB FRACP PhD BSc (Hons) PhD Co-Head, Brain Tumour Research Brainchild Fellow; Co-Head, Brain Tumour Research nicholas.gottardo@telethonkids.org.au raelene.endersby@telethonkids.org.au Co-Head, Brain Tumour ...

        Research

        The AIM-BRAIN Project: Access to Innovative Molecular diagnostic profiling for paediatric brain tumours

        Nick Gottardo NG MBChB FRACP PhD Co-Head, Brain Tumour Research nicholas.gottardo@telethonkids.org.au Co-Head, Brain Tumour Research Professor Nick Gottardo co-leads the Brain Tumour Research Programme at the Telethon Kids Institute. He is also Head ...

        Research

        Chemotherapy increases amenability of surgical resection in congenital glioblastoma

        Brain tumors presenting in infancy, especially during the first 6 months of life. ...

        Research

        Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

        Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphoblastic leukemia (T-ALL) mainly occurs at promoters of Polycomb Repressor Complex 2 (PRC2) target genes that are not expressed in normal or malignant T-cells and which display a reciprocal association with H3K27me3 binding. ...

        Research

        Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: Report of a case and review of the literature

        Rishi Sury Nick Kotecha Gottardo RS NG MB ChB (Hons) MRCPCH FRACP PhD MBChB FRACP PhD Co-Head, Leukaemia Translational Research Co-Head, Brain Tumour Research rishi.kotecha@health.wa.gov.au nicholas.gottardo@telethonkids.org.au Co-Head, Leukaemia ...

        Research

        Pre-natal, clonal origin of t(1;11)(p32;q23) acute lymphoblastic leukemia in monozygotic twins

        Investigation of this rare mixed lineage leukemia cytogenetic abnormality aims to provide further evidence of the genetic changes that underpin this leukemia. ...

        Research

        Bilateral murine tumor models for characterizing the response to immune checkpoint blockade

        This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade ...

        Research

        The Australian New Zealand Consortium in Children, Adolescents, and Young Adults Oncofertility action plan

        International and national oncofertility networks, including the US-led Oncofertility Consortium, FertiProtekt, and the Danish Network, have played pivotal roles in advancing the discipline of oncofertility over the last decade. Many other countries lack a shared approach to pediatric oncofertility health service delivery. ...

        Research

        Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

        We report on 3 children treated with vismodegib who developed widespread growth plate fusions that persist long after cessation of therapy. ...

        Research

        Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL

        GATA3low ETP-ALL is a novel stem cell-like leukemia with implications for the use of myeloid-derived therapies ...

        Research

        Factors relating to pregnancy and birth and the risk of childhood brain tumors: Results from an Australian case-control study

        Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their causes are largely known. This study investigated the association... ...

        Page 26 of 57