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        301-312 of 1073 results for 'curtin'

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        Mapping changes in housing in sub-Saharan Africa from 2000 to 2015

        Our maps provide a baseline for measuring change and a mechanism to guide interventions during the era of the Sustainable Development Goals ...

        Research

        Occurrence and timely management of problems requiring prompt intervention among Indigenous compared with non-Indigenous Australian palliative care patients: A multijurisdictional cohort study

        Anticipation and prompt relief of symptoms among patients with a life-limiting illness is a core element of palliative care. Indigenous Australians commonly encounter cultural barriers in healthcare that may impair outcomes. The Palliative Care Outcomes Collaboration collects patient care data for the purposes of continuous quality improvement and benchmarking, with each recorded care episode divided into phases that reflect a patient's condition. ...

        Research

        Pharmacokinetics of intramuscular versus subcutaneous administration of Benzathine Penicillin G

        Jonathan Rosemary Carapetis AM Wyber JR R AM MBBS FRACP FAFPHM PhD FAHMS MBChB MPH FRACGP PhD Executive Director; Head, Strep A Translation; Co-Founder of REACH Senior Research Fellow 08 6319 1000 contact@telethonkids.org.au Institute Director; Head ...

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        The critical role of the bone marrow stromal microenvironment for the development of drug screening platforms in leukemia

        Extensive research over the past 50 years has resulted in significant improvements in survival for patients diagnosed with leukemia. Despite this, a subgroup of patients harboring high-risk genetic alterations still suffer from poor outcomes. There is a desperate need for new treatments to improve survival, yet consistent failure exists in the translation of in vitro drug development to clinical application. ...

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        FDA-approved disulfiram as a novel treatment for aggressive leukemia

        Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach. ...

        Research

        Reidentification with Birth-Registered Sex in a Western Australian Pediatric Gender Clinic Cohort

        Some young people who identify as transgender and seek gender-affirming medical care subsequently reidentify with their sex registered at birth. Evidence regarding the frequency and characteristics of this experience is lacking.  ...

        Research

        Lung inflammation and simulated airway resistance in infants with cystic fibrosis

        Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. ...

        Research

        Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

        Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warrant the urgent development of more effective and cancer-selective therapeutics. ...

        Research

        A Review of Cardiac Surgical Procedures and Their Outcomes for Paediatric Rheumatic Heart Disease in Western Australia

        Surgical intervention is an important treatment modality for advanced rheumatic heart disease (RHD). This study aimed to describe patient characteristics and outcomes from cardiac surgery for RHD in patients referred to the only tertiary paediatric hospital in Western Australia.  ...

        Research

        Environmental and social determinants of acute rheumatic fever: a longitudinal cohort study

        Prevention strategies in ARF endemic settings may be enhanced by targeting new members entering a community and children in environments of close contact ...

        Research

        Respiratory function and symptoms in young preterm children in the contemporary era

        Preterm children have worse lung function than healthy controls ...

        Research

        Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemia

        Our findings shed light on the mechanisms of leukemia-induced bone loss ...

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