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        313-324 of 785 results for 'asthma'

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        High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy

        The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K. pneumoniae (CRkp). ...

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        Multiple traces of monkeypox detected in non-sewered wastewater with sparse sampling from a densely populated metropolitan area in Asia

        The monkeypox virus is excreted in the feces of infected individuals. Therefore, there is an interest in using viral load detection in wastewater for sentinel early surveillance at a community level and as a complementary approach to syndromic surveillance. ...

        Research

        Innate immune activation occurs in acute food protein–induced enterocolitis syndrome reactions

        Food reactions in food protein–induced enterocolitis syndrome are predominantly underpinned by activation of the innate immune system ...

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        Unlocking immune-mediated disease mechanisms with transcriptomics

        The transcriptome represents the entire set of RNA transcripts expressed in a cell, reflecting both the underlying genetic and epigenetic landscape and environmental influences, providing a comprehensive view of functional cellular states at any given time. Recent technological advances now enable the study of the transcriptome at the resolution of individual cells, providing exciting opportunities to characterise cellular and molecular events that underpin immune-medicated diseases. ...

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        Ground zero—the airway epitheliumNew Page

        This chapter will discuss the structure of the airway highlighting the now broad number of cell types that comprise it ...

        Research

        Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

        There are moderate associations between vitamin D status measured in prepuberty, adolescence, and early adulthood ...

        Research

        Associations between respiratory and vascular function in early childhood

        The link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity. ...

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        Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

        Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-gamma... ...

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        Immune modulation by UV: Role of vitamin D

        In this chapter, evidence for and evidence against the involvement of vitamin D in the immunoregulatory properties of UV radiation is presented. ...

        Research

        Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive

        Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are often linked to respiratory infections. ...

        Research

        PIFA - Pertussis and Food allergy, a case-cohort study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy

        Pat Peter Tom Holt Richmond Snelling PG PC T PhD, DSc, FRCPath, FRCPI, FAA MBBS MRCP(UK) FRACP BMBS DTMH GDipClinEpid PhD FRACP Emeritus Honorary Researcher Head, Vaccine Trials Group Head, Infectious Disease Implementation Research 08 6319 1817 ...

        Research

        Time spent outdoors through childhood and adolescence - assessed by 25-hydroxyvitamin D concentration - and risk of myopia at 20 years

        To investigate the relationship between time spent outdoors, at particular ages in childhood and adolescence, and myopia status in young adulthood using serum 25-hydroxyvitamin D [25(OH)D] concentration as a biomarker of time spent outdoors. Participants of the Raine Study Generation 2 cohort had 25(OH)D concentrations measured at the 6-, 14-, 17- and 20-year follow-ups. Participants underwent cycloplegic autorefraction at age 20 years, and myopia was defined as a mean spherical equivalent -0.50 dioptres or more myopic. Logistic regression was used to analyse the association between risk of myopia at age 20 years and age-specific 25(OH)D concentrations. Linear mixed-effects models were used to analyse trajectory of 25(OH)D concentrations from 6 to 20 years. ...

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