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        325-336 of 671 results for 'early childhood education'

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        Can joined-up data lead to joined-up thinking? The Western Australian Developmental Pathways Project

        Modern societies are challenged by "wicked problems" - by definition, those that are difficult to define, multi-casual and hard to treat. ...

        Research

        Early respiratory viral infections in infants with cystic fibrosis

        Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens ...

        Research

        ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma

        COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

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        Airway surface liquid pH is not acidic in children with cystic fibrosis

        Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

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        Early lung disease in infants and preschool children with cystic fibrosis: What have we learned and what should we do about it?

        This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for clinical practice and research ...

        Research

        Structural determinants of long term functional outcomes in young children with cystic fibrosis

        Chest CT identifies children at an early age who have adverse long-term outcomes ...

        Research

        Microbiomic Analysis on Low Abundant Respiratory Biomass Samples; Improved Recovery of Microbial DNA From Bronchoalveolar Lavage Fluid

        In recent years the study of the commensal microbiota is driving a remarkable paradigm shift in our understanding of human physiology. However, intrinsic technical difficulties associated with investigating the Microbiomics of some body niches are hampering the development of new knowledge. This is particularly the case when investigating the functional role played by the human microbiota in modulating the physiology of key organ systems. A major hurdle in investigating specific Microbiome communities is linked to low bacterial density and susceptibility to bias caused by environmental contamination. ...

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        Vulnerable from the first breath - epithelial dysfunction and respiratory outcomes in children

        Anthony David Stephen Susan Kicic Martino Stick Prescott A DM SM SL BSc (Hons) PhD BSc PhD MB BChir PhD MRCP FRACP MBBS BMedSci PhD FRACP Rothwell Family Fellow; Head, Airway Epithelial Research Head, Clinical Epigenetics Head, P4 Respiratory Health ...

        Research

        A preliminary study of fetal head circumference growth in Autism Spectrum Disorder

        Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ...

        Research

        Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis

        We hypothesized that the presence of these markers of cystic fibrosis lung disease in the first 2 years of life would be associated with reduced lung... ...

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        Community participation for girls and women living with Rett syndrome

        Participation for girls and women with Rett syndrome could be enhanced by stronger local community supports. ...

        Research

        Developmental vulnerabilities in children of chronically ill parents: A population-based linked data study

        Maternal chronic illness is associated with an increased risk of poor developmental outcomes for children, particularly daughters ...

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