The microbiome is intimately connected to diet, nutrition, and other lifestyle variables ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• May 2016

Nutrition in early childhood may have a long-term association with fundamental cognitive processing speed, which is likely to be related to enhanced brain... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• February 2015

CDKL5 Deficiency Disorder (CDD) is a rare genetic disorder caused by a mutation in the cyclin-dependent kinase-like 5 (CDKL5) gene. It is now considered to be a developmental and epileptic encephalopathy because of the early onset of seizures in association with severe global delay. Other features include cortical visual impairment, sleep and gastro-intestinal problems. Progress in clinical understanding, especially regarding the spectrum of functional ability, seizure patterns, and other comorbidities was initially slow but accelerated in 2012 with the establishment of the International CDKL5 Database (ICDD). Our aim was to use this data source to investigate quality of life (QOL) and associated factors in this disorder. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Amy Keerthi Jenny Daniel Finlay-Jones Kottampally Downs Ta AFJ KK JA DT BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) Bsc (Hons), GradDipPsych(Adv) BApplSci (physio) MSc PhD BBiomedSc (Hons) Head, Early Neurodevelopment & Mental ...

• 1. Telethon Kids Institute
• Projects

We compared neonatal T reg from children born in western conditions (Australia) with those of neonates born in high microbial conditions (Papua New Guinea)... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• March 2012

The structure and function of infant skin is not fully developed until 34 weeks of gestation, and this immaturity is associated with risk of late-onset sepsis (LOS). Topical coconut oil improves preterm-infant skin integrity and may reduce LOS. However, data on early-life skin-microbiome succession and potential effects of emollient skin care in preterm infants are scarce. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

Despite their increasing popularity, and Australia's unique regulatory environment, how and why Australian adults use e-cigarettes and their perceptions of their safety, efficacy and regulation have not been extensively reported before. In this study, we screened 2217 adult Australians with the aim of assessing these questions in a sample of current or former e-cigarette users. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Atmospheric carbon dioxide (CO2) levels are currently at 418 parts per million (ppm), and by 2100 may exceed 900 ppm. The biological effects of lifetime exposure to CO2 at these levels is unknown. Previously we have shown that mouse lung function is altered by long-term exposure to 890 ppm CO2. Here, we assess the broader systemic physiological responses to this exposure. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

It is therefore clear that gavage can have significant impacts on experimental animals in terms of their stress response and overall morbidity and mortality ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Despite the teratogenic effects of alcohol, little is known about the safety of pharmacotherapies such as acamprosate for the treatment of alcohol use disorders in pregnancy. The aims of this study were to investigate, in a mouse model, the effects of maternally administered acamprosate on maternal and neonatal health, offspring neurodevelopment and behaviour, as well as examine whether acamprosate reduces the neurological harm associated with alcohol consumption in pregnancy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Climate change models predict that atmospheric carbon dioxide [CO2] levels will be between 700 and 900 ppm within the next 80yrs. In this study we aimed to assess the respiratory structure and function effects of long-term exposure to 890ppm CO2 from preconception to adulthood using a mouse model. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Epidemiological studies indicate that exposure to diesel exhaust (DE) is associated with vascular-based disorders. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014