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        337-348 of 1037 results for '2013'

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        Modelling respiratory syncytial virus age-specific risk of hospitalisation in term and preterm infants

        Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infections in children worldwide. The highest incidence of severe disease is in the first 6 months of life, with infants born preterm at greatest risk for severe RSV infections.  ...

        Research

        Profile of severely growth-restricted births undelivered at 40 weeks in Western Australia

        Higher levels of poor perinatal outcomes among FGR births highlight the importance of appropriate management including fetal growth monitoring ...

        Research

        Mapping the endemicity and seasonality of clinical malaria for intervention targeting in Haiti using routine case data

        Towards the goal of malaria elimination on Hispaniola, the National Malaria Control Program of Haiti and its international partner organisations are conducting a campaign of interventions targeted to high-risk communities prioritised through evidence-based planning. Here we present a key piece of this planning: an up-to-date, fine-scale endemicity map and seasonality profile for Haiti informed by monthly case counts. ...

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        A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study

        Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab. ...

        Research

        Comparison of group A streptococcal titres in healthy children and those with pharyngitis and skin infections

        Rates of acute rheumatic fever, a sequelae of group A Streptococcal (GAS) infection, remain unacceptably high in Indigenous Māori and Pacific children in New Zealand. This prospective study aimed to describe GAS antibody titres in healthy children (5–14 years) by ethnicity, and to determine how paired titres vary with GAS culture positive and negative pharyngitis, and GAS skin infections. ...

        Research

        Global epidemiology of valvular heart disease

        Valvular heart disease is a major contributor to loss of physical function, quality of life and longevity. The epidemiology of VHD varies substantially around the world, with a predominance of functional and degenerative disease in high-income countries, and a predominance of rheumatic heart disease in low-income and middle-income countries. Reflecting this distribution, rheumatic heart disease remains by far the most common manifestation of VHD worldwide and affects approximately 41 million people. ...

        Research

        Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

        The age-standardized disability-adjusted life years rates in the Eastern Mediterranean Region are considerably higher than the global average. ...

        Research

        Online interventions for the mental health needs of trans and gender diverse young people

        Members of our research team have done an online survey (Trans Pathways) exploring the mental health and care pathways of gender diverse youth in Australia. ...

        Research

        A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.

        This publication is a systematic analysis of all Group A Streptococcus M protein variants, to assist in the development of a vaccine. ...

        Research

        Invasive group A streptococcal infection in the Northern Territory, Australia: Case report and review of the literature

        This review article presents the case of infant Aboriginal twins with invasive group A streptococcal infection complicated by streptococcal toxic shock... ...

        Research

        Prevalence of rheumatic heart disease in young adults from New Caledonia

        The prevalence of echocardiographically diagnosed RHD in adults in New Caledonia is estimated at 5.9 per 1000 ...

        Research

        Developing a Model to Account for Attrition Bias in a Longitudinal Cohort

        Our objective was to develop a method that could be applied in a longitudinal cohort study to account for attrition bias in an investigation of exclusive... ...

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