Browse study websites

Discover. Prevent. Cure.

Menu Fundraise Donate

    Recommended pages

      Do you mean

        337-348 of 439 results for 'Rare disease'

        Refine research

        Research

        Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil

        Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. ...

        Research

        Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

        Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin... ...

        Research

        Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil

        Our results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis ...

        Research

        Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data

        Here we compare the performance of several LMM approaches (and software implementations, including EMMAX, GenABEL, FaST-LMM, Mendel, GEMMA and MMM) via their... ...

        Research

        Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

        We found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. ...

        Research

        A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

        These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data ...

        Research

        P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

        The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacte ...

        Research

        Immunogenicity and safety of single-dose, 13-valent pneumococcal conjugate vaccine in pediatric and adolescent oncology patients

        All children who are receiving therapy for cancer should receive a single dose of PCV13 as soon as possible after diagnosis, regardless of prior PCV exposure. ...

        Research

        First genome-wide association study in an Australian Aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes

        A body mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians. ...

        Research

        The clinical and molecular epidemiology of Staphylococcus aureus infections in Fiji

        We observed S. aureus infections in Fiji in both community and hospital settings with an emphasis on clonal complex genotyping and antimicrobial susceptibility. ...

        Research

        Mapping mammalian cell-type-specific transcriptional regulatory networks using KD-CAGE and ChIP-seq data in the TC-YIK cell line.

        Examining the overlap between genes perturbed in the KD-CAGE experiments and genes with a ChIP-seq peak within 50 kb of their promoter, we identified direct... ...

        Research

        Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

        Identified romidepsin as a promising therapeutic for mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia ...

        Page 29 of 37