Results indicated a strong familial basis of melanoma, with the higher than expected hazard ratio observed likely to reflect early-age at onset cases in this... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

Blood-based markers for malignant mesothelioma (MM), particularly soluble mesothelin and osteopontin, are currently of great clinical interest. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

Given the paucity of data concerning long-term outcome, the authors undertook a meta-analysis to analyze morbidity in survivors of this disease. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• September 2013

Patients with high-risk or metastatic Ewing sarcoma (ES) and rhabdomyosarcoma (RMS) have a guarded prognosis. High-dose chemotherapy (HDT) with autologous stem cell transplant (ASCT) has been evaluated as a treatment option to improve outcomes. However, survival benefits remain unclear, and treatment is associated with severe toxicities. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

This multi-center study provides valuable information on the success rate of establishing patient-derived pre-clinical models of diffuse intrinsic pontine glioma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

This study demonstrates that exercise is achievable and has positive effects on vascular function, submaximal fitness, local strength and physical activity in a population of AYA survivors of pediatric oncology related cerebral insult ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warrant the urgent development of more effective and cancer-selective therapeutics. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

This study thus identified a novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulnerability ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• May 2019

The outcome of infants with KMT2A-germline acute lymphoblastic leukaemia (ALL) is superior to that of infants with KMT2A-rearranged ALL but has been inferior to non-infant ALL patients. Here, we describe the outcome and prognostic factors for 167 infants with KMT2A-germline ALL enrolled in the Interfant-06 study. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%. In total, 83% (n = 20/24) proceeded to haematopoietic stem cell transplant, directly after blinatumomab (n = 12) or following additional salvage therapy (n = 8). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

Epidermal growth factor receptor (EGFR) is over-expressed in many brain tumors. This paper examines mutations the EGFR that make the cell it is produced in... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• April 2014

Bacillus cereus can cause serious infections in immunosuppressed patients. This population may be susceptible to B. cereus pneumonia, bacteremia, cellulitis,... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• April 2013