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        Outcomes for Australian children with relapsed/refractory acute lymphoblastic leukaemia treated with blinatumomab

        We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%. In total, 83% (n = 20/24) proceeded to haematopoietic stem cell transplant, directly after blinatumomab (n = 12) or following additional salvage therapy (n = 8). ...

        Research

        Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiation

        This study investigates the different patterns of relapse in patients with central nervous system mixed malignant germ cell tumors - treated with chemotherapy. ...

        Research

        Efficacy of acute myeloid leukemia therapy without stem-cell transplantation in a child with blastic plasmacytoid dendritic cell neoplasm

        Our case demonstrates that AML therapy, without HSCT, can be sufficient to treat this rare disease in children. ...

        Research

        Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity

        Epidermal growth factor receptor (EGFR) is over-expressed in many brain tumors. This paper examines mutations the EGFR that make the cell it is produced in... ...

        Research

        Grey matter changes associated with deficit awareness in mild cognitive impairment: A voxel-based morphometry study

        We examined the association of insight and grey matter volume using a voxel-based morphometry approach in volunteers with and without mild cognitive impairment. ...

        Research

        Parental occupational exposure to engine exhausts and childhood brain tumors

        Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. ...

        Research

        Cancer incidence and mortality trends in Australian adolescents and young adults, 1982-2007

        The objective of this study was to describe overall and type-specific cancer incidence and mortality trends among AYAs in Western Australia from 1982-2007... ...

        Research

        Statistical adjustment of genotyping error in a case-control study of childhood leukaemia

        Genotyping has become more cost-effective and less invasive with the use of buccal cell... ...

        Research

        Fusionfinder: A software tool to identify expressed gene fusion candidates from RNA-seq data

        The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions. ...

        Research

        Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cells

        Medulloblastoma (MB) is the most common type of malignant childhood brain tumour. ...

        Research

        Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: A population-based cohort study

        Female survivors of AYA cancer have moderate excess risks of adverse obstetric and perinatal outcomes arising from subsequent pregnancies ...

        Research

        Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

        Cancer immunotherapy has shown impressive results, but most patients do not respond. ...

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