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        Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood

        The dramatic increase in the prevalence of allergic disease in recent decades reflects environmental and behavioural changes that have altered patterns of early immune development. The very early onset of allergic diseases points to the specific vulnerability of the developing immune system to environmental changes and the development of primary intervention strategies is crucial to address this unparalleled burden. ...

        Research

        Toxicity of different biodiesel exhausts in primary human airway epithelial cells grown at air-liquid interface

        Biodiesel is created through the transesterification of fats/oils and its usage is increasing worldwide as global warming concerns increase. Biodiesel fuel properties change depending on the feedstock used to create it. ...

        Research

        A pilot study of disease related education and psychotherapeutic support for unresolved grief in parents of children with CF

        Diagnosis of chronic disease in a child can result in unresolved grief (UG) in parents. This study aimed to evaluate the efficacy of psychological insight-oriented therapy (IOT) as a treatment for UG compared to disease related education in parents of children with cystic fibrosis. Sequence of delivery, first IOT then disease related education (or vice versa) was also examined, to let all participants experience both interventions. ...

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        Nasal delivery of a commensal Pasteurellaceae species inhibits nontypeable Haemophilus influenzae colonisation and delays onset of otitis media in mice

        We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo ...

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        Early respiratory viral infections in infants with cystic fibrosis

        Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens ...

        Research

        Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue

        Non-burning (low-dose) UVR suppresses the BAT 'whitening', steatotic and pro-diabetic effects of consuming a high-fat diet through skin release of nitric oxide ...

        Research

        Whole genome and biomarker analysis of patients with recurrent glioblastoma on bevacizumab: A subset analysis of the CABARET trial.

        Whole genome sequencing of poor and exceptional survivors identified a gain in Chromosome 19 that was exclusive to the exceptional survivors ...

        Research

        Spatial patterns of tuberculosis and HIV coinfection in Ethiopia

        Our study provides evidence for geographic clustering of tuberculosis/human immunodeficiency virus co-infection in Ethiopia ...

        Research

        Genetic Manipulation of Group A Streptococcus-Gene Deletion by Allelic Replacement

        An optimized, rapid method for creating markerless isogenic mutations that combines Gibson assembly cloning with a new temperature-sensitive plasmid, pLZts ...

        Research

        Towards the development of an integrative, evidence-based suite of indicators for the prediction of outcome following mild traumatic brain injury

        Performance on neuropsychological measures may be useful for predicting persisting post-concussion symptoms ...

        Research

        Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma model

        We established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model ...

        Research

        Early life determinants of health: Invest early to break the cycle of long-term disadvantage in neurodevelopmental disorders

        This chapter discusses the importance of investment in early life determinants of health to break the cycle of long-term disadvantage. This chapter addresses these issues while focussing on neurodevelopmental disorders and their related mental health concerns as the targets at the centre of a biopsychosocial transformation of the health system. ...

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