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        Two females with mutations in USP9X highlight the variable expressivity of the intellectual disability syndrome

        The genetic causes of intellectual disability (ID) are heterogeneous and include both chromosomal and monogenic etiologies. ...

        Research

        Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

        Genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment ...

        Research

        What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analyses

        There remains uncertainty about the effect of exercise on oxidative stress in people with Down syndrome ...

        Research

        Evidence of functional cell-mediated immune responses to nontypeable Haemophilus influenzae in otitis-prone children

        These data provide evidence that otitis-prone children do not have impaired functional cell mediated immunity ...

        Research

        Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

        We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

        Research

        Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics

        Here, we show that conditionally reprogrammed airway epithelial cells (CRAECs) can be established from both healthy and diseased phenotypes. ...

        Research

        Regular exercise improves the well-being of parents of children with cancer

        Mental health benefits of a pedometer-based exercise intervention for parents of children with cancer were identified. ...

        Research

        Early autism symptoms in infants with tuberous sclerosis complex

        We examined early signs of ASD in infants wit tuberous sclerosis complex, approximately 50% of whom will meet criteria for ASD by age 3. ...

        Research

        Investigating the long-term impact of a childhood sun-exposure intervention, with a focus on eye health: protocol for the Kidskin-Young Adult Myopia Study

        A follow-up of Kidskin Study participants provides an opportunity to investigate the associations between a childhood sun-exposure intervention and potentially related conditions in adulthood ...

        Research

        Effects of maltreatment and parental schizophrenia spectrum disorders on early childhood social-emotional functioning: a population record linkage study

        We used data from a large Australian population to determine the independent and moderating effects of maltreatment and parental SSDs on early childhood. ...

        Research

        Barriers to Addressing Social Determinants of Health in Pediatric Nursing Practice: An Integrative Review

        The greatest barrier to addressing the social determinants of health in the pediatric context is the dominance of the 'medical model' of care ...

        Research

        Functional differences in airway dendritic cells determine susceptibility to IgE-sensitization

        Respiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma. ...

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