This manuscript will give a brief overview of clinical trial design including the strengths and limitations of various approaches ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

The burden of bronchiectasis is disproportionately high in Aboriginal adults, with early mortality. Bronchiectasis precursors, that is, protracted bacterial bronchitis and chronic suppurative lung disease, often commence in early childhood. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Jacinta Freeman JF BScs, MPH Program Manager, Youth Mental Health 6319 1699 Jacinta.freeman@telethonkids.org.au Program Manager she/her/hers Jacinta has a background in nursing and midwifery. She completed a Master in Public Health and has worked ...

• 1. Telethon Kids Institute
• Projects
• Past projects

Bronchiectasis, particularly in children, is an increasingly recognised yet neglected chronic lung disorder affecting individuals in both low-to-middle and high-income countries. It has a high disease burden and there is substantial inequity within and between settings. Furthermore, compared with other chronic lung diseases, considerably fewer resources are available for children with bronchiectasis.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• March 2024

Natural killer (NK) cells have an intrinsic ability to detect and eliminate leukaemic cells. Cellular therapies using cytokine-activated NK cells have emerged as promising treatments for patients with advanced leukaemia. However, not all patients respond to current NK cell therapies, and thus improvements in efficacy are required. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Lung abscess is a rare condition in paediatrics with a paucity of literature. Intravenous antibiotics is the main therapy; however interventional radiological approaches have led to the use of percutaneous drainage. Surgery is reserved for the management of complications. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

Interstitial lung disease in children comprises a range of different rare diseases ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbiosis of the intestinal microbiota can have a substantial effect on the nervous and immune systems, contributing to the onset of several inflammatory diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Retinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Despite advances in cystic fibrosis (CF) management and survival, the optimal treatment of pulmonary exacerbations remains unclear. Understanding the variability in treatment approaches among physicians might help prioritise clinical uncertainties to address through clinical trials. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

High-flow nasal oxygen (HFNO) is frequently used in hospitals, producing droplets and aerosols that could transmit SARS-CoV-2. Our aim was to determine if a headbox could reduce droplet and aerosol transmission from patients requiring HFNO. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Nick Nicholas Sherlynn Golding Tierney Ang NG NT SA BSc DPhil B.Psych.Sci (Hons), PhD (Statistics) BSc(Hons) Honorary Research Fellow Research Software Engineer Project Manager Nick.Golding@telethonkids.org.au nicholas.tierney@telethonkids.org.au ...

• 1. Telethon Kids Institute
• Projects