Electronic cigarettes (e-cigarettes) are often perceived to be safer than smoking, which has led to some women switching to e-cigarettes during pregnancy. However, the effects of switching from smoking to e-cigarettes on both pregnancy outcomes and the foetus are largely unknown. This study aimed to investigate the effects of switching from tobacco smoking to e-cigarette use in very early pregnancy on birth outcomes, neurodevelopment and behaviour of the offspring. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Idiopathic pulmonary fibrosis (IPF) is characterized by permanent scarring of lung tissue and declining lung function, and is an incurable disease with increase in prevalence over the past decade. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

This study tested the utility of optical coherence tomography-based indentation to assess mechanical properties of respiratory tissues in disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the disease and the impact of current therapies are limited. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Authors: Zosky GR, Noble PB, Sly PD. Authors notes: J Appl Physiol. 2010 Sep;109(3):935; author reply 937. Keywords: Commentaries, Viewpoint: Standards for quantitative assessment of lung structure. Instillation fixation and overinflation of the ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• September 2010

The Deep Genome Project—to deliver the functional biological annotation of all human orthologous genomic elements in mice ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Current approaches to staging chronic liver diseases have limited utility for predicting liver cancer risk. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using two distinct mouse models. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

Effective antitumor CD8 T cell responses may be activated by directly targeting the innate immune system within tumors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2008
• February 2008

We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• August 2009

Our data demonstrate a causal relationship between activating Pik3ca mutations and the genesis of venous malformations ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• March 2016