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        Novel end points for clinical trials in young children with cystic fibrosis

        Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality. ...

        Research

        Defining the appropriate waiting time between multiple-breath nitrogen washout measurements

        This letter addresses the recommendations by the American Thoracic Society & European Respiratory Society in 2005, that patients must wait 15-60mins between... ...

        Research

        A novel, palatable paediatric oral formulation of midazolam: Pharmacokinetics, tolerability, efficacy and safety

        We conclude that the novel chocolate-based formulation of midazolam provides improved tolerability while remaining efficacious ...

        Research

        Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

        Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure ...

        Research

        The clinical utility of lung clearance index in early cystic fibrosis lung disease is not impacted by the number of multiple-breath washout trials

        This study aimed to determine if relationships between LCI and clinical outcomes of CF lung disease differ when only two acceptable MBW trials are assessed. ...

        Research

        Associations between respiratory and vascular function in early childhood

        The link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity. ...

        Research

        Which reference equation should we use for interpreting spirometry values for First Nations Australians? A cross-sectional study

        To evaluate the suitability of the Global Lung Function Initiative (GLI)-2012 other/mixed and GLI-2022 global reference equations for evaluating the respiratory capacity of First Nations Australians.  ...

        Research

        Determinants of lung function development from birth to age 5 years: an interrupted time series analysis of a South African birth cohort

        Early life is a key period that determines long-term health. Lung development in childhood predicts lung function attained in adulthood and morbidity and mortality across the life course. We aimed to assess the effect of early-life lower respiratory tract infection (LRTI) and associated risk factors on lung development from birth to school age in a South African birth cohort. ...

        Research

        Early life exposure to coal mine fire smoke emissions and altered lung function in young children

        Infant exposure to coal mine fire emissions could be associated with long-term impairment of lung reactance ...

        Research

        Impact of HIV and antiretroviral drug exposure on lung growth and function over 2 years in an African Birth Cohort

        HIV exposure is associated with altered lung function in early life, with a vulnerable HIV-exposed uninfected subgroup based on maternal disease severity ...

        Research

        Single-breath washout and association with structural lung disease in children with cystic fibrosis

        Acinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT ...

        Research

        ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

        Assessment of airway hyperresponsiveness are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy ...

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