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        A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery

        Predicting treatment response or survival of cancer patients remains challenging in immuno-oncology. Efforts to overcome these challenges focus, among others, on the discovery of new biomarkers. Despite advances in cellular and molecular approaches, only a limited number of candidate biomarkers eventually enter clinical practice. ...

        Research

        Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: Findings from Trans Pathways

        The current results highlight the urgent need for better mental health care and provide insight into areas for targeted mental health interventions ...

        Research

        Does Child Care in the First Year of Life Pose a Risk for Concurrent and Future Ear Infections?

        The longitudinal analyses found no evidence of increased (or decreased) long-term risk of ear infections in subsequent waves associated with attending a child care centre ...

        Research

        Determinants for progression from asymptomatic infection to symptomatic visceral leishmaniasis: A cohort study

        We confirmed the strong association between high DAT and/or rK39 titers and progression to disease among asymptomatic subjects ...

        Research

        Epidemiology and risk factors for recurrent severe lower limb cellulitis: a longitudinal cohort study

        Severe lower leg cellulitis recurrences are frequent, and each episode increases the likelihood of subsequent recurrence and length of hospitalization ...

        Research

        Maternal alcohol disorders and school achievement: a population cohort record linkage study in Western Australia

        Children of mothers with alcohol use disorders are at risk of not meeting minimum educational benchmarks in numeracy and literacy, with the risk highest among Indigenous children. ...

        Research

        Evaluation of impact of 23 valent pneumococcal polysaccharide vaccine following 7 valent pneumococcal

        The impact of the 23vPPV booster on IPD incidence among Australian Indigenous children is unclear from regional reports of small case numbers. ...

        Research

        Association of gestational age at birth with reasons for subsequent hospitalisation: 18 Years of follow-up in a Western Australian population study

        Preterm infants are at a higher risk of hospitalisation following discharge from the hospital after birth. ...

        Research

        Jurisdictional, socioeconomic and gender inequalities in child health and development:

        Early child development may have important consequences for inequalities in health and well-being. This paper explores population level patterns of child... ...

        Research

        Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

        Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits... ...

        Research

        Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea

        Vaccination trials in high endemicity areas are needed to provide evidence and guidance on idea strategies to protect children in these areas against infections ...

        Research

        A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

        These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data ...

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