Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

Over the past 20 years natural killer (NK) cell-based immunotherapies have emerged as a safe and effective treatment option for patients with relapsed or refractory leukemia. Unlike T cell-based therapies, NK cells harbor an innate capacity to eliminate malignant cells without prior sensitization and can be adoptively transferred between individuals without the need for extensive HLA matching. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Consideration of the future for asbestos-related lung disease includes screening those at highest risk ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

We evaluated baseline data from the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681) on the association between behavioral risk factors... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• December 2012

Timo W. Joost Lassmann Lesterhuis T WJL BSc (Hons) MSc PhD Feilman Fellow; Program Head, Precision Health and Team Lead, Computational Biology Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head timo.lassmann@telethonkids.org.au ...

• Telethon Kids Institute
• Projects

This article summarizes data from collaborative group and institutional trials that have advanced the science of pediatric brain tumors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• August 2015

Childhood acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and brain tumors (CBTs) are the leading cause of cancer death in... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

We hypothesized that reactivation of p53 by inhibition of its negative regulator will result in p53-mediated growth arrest and apoptosis. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• August 2009

Present a valuable resource for drug discovery and have identified ROM as a promising therapeutic for MLL-rearranged iALL ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

All children who are receiving therapy for cancer should receive a single dose of PCV13 as soon as possible after diagnosis, regardless of prior PCV exposure. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Presenting features, biology and outcome for childhood leukaemia are known to vary by ethnic origin, geographic location and socioeconomic group. This study aimed to compare presentation patterns, follow-up and clinical outcomes in Indigenous and non-Indigenous children with acute leukaemia in Australia, and to assess the impact of remoteness and area-based socioeconomic disadvantage on outcome. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021