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        361-372 of 4107 results for 'Au'

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        Reduced socs1 expression in lung fibroblasts from patients with ipf is not mediated by promoter methylation or mir155

        The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and function are unknown. Suppressor of cytokine signaling (SOCS)1 and SOCS3 block STAT3, and low SOCS1 levels have been reported in IPF fibroblasts and shown to facilitate collagen production. Fibroblasts and lung tissue from IPF patients and controls were used to examine the mechanisms underlying SOCS1 down-regulation in IPF. ...

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        Tumor Infiltrating Effector Memory Antigen-Specific CD8(+) T Cells Predict Response to Immune Checkpoint Therapy

        Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. ...

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        The impact on service collaboration of co-location of early childhood services in tasmanian child and family centres: An ethnographic study

        There is a global trend towards place-based initiatives (PBIs) to break the cycle of disadvantage and promote positive child development. Co-location is a common element of these initiatives and is intended to deliver more coordinated services for families of young children. This paper examines how co-locating early childhood services (ECS) from health and education in Child and Family Centres (CFCs) has impacted collaboration between services. ...

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        Telling an Adult at School about Bullying: Subsequent Victimization and Internalizing Problems

        To prevent persistent victimization, schools and teachers need to be better equipped to respond effectively when a student first becomes a target of bullying ...

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        Cancer therapies inducing DNA damage

        The induction of DNA damage has been employed as an anticancer strategy for more than 100years, first starting with the use of radiation to treat stomach cancer followed by the first uses of DNA-damaging chemotherapy to treat childhood leukemia. ...

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        Reporting Both Unadjusted and Adjusted Estimates Is Essential to the Interpretation of Randomized Clinical Trial Results - Reply

        Andrew Matt Whitehouse Watch and listen to Andrew Cooper AJ MC PhD BCA Marketing, BSc Statistics and Applied Statistics, PhD Angela Wright Bennett Professor of Autism Research at Telethon Kids Institute; Director, CliniKids Manager, Biometrics 08 ...

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        Comparative effectiveness of interventions for preventing tuberculosis: systematic review and network meta-analysis of interventional studies

        Tuberculosis (TB) is the leading infectious cause of death globally. Several preventive measures are employed to prevent TB, yet there is a paucity of evidence on the effectiveness of these interventions. Therefore, this study aimed to identify the most effective interventions for reducing TB incidence. ...

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        Biodiesel Exhaust Toxicity with and without Diethylene Glycol Dimethyl Ether Fuel Additive in Primary Airway Epithelial Cells Grown at the Air-Liquid Interface

        Biodiesel usage is increasing steadily worldwide as the push for renewable fuel sources increases. The increased oxygen content in biodiesel fuel is believed to cause decreased particulate matter (PM) and increased nitrous oxides within its exhaust. ...

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        Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: An integrative review

        We review medical conditions that have been repeatedly highlighted as sharing the strongest associations with ASD-epilepsy, sleep, as well as gastrointestinal and immune functioning ...

        Research

        Testing for Response Shift Bias in Evaluations of School Antibullying Programs

        Researchers conducting program evaluations in other contexts are advised to consider testing for this potential source of bias in their studies ...

        Research

        Prenatal alcohol exposure and educational achievement in children aged 8-9 years

        This study examines the relationships between the dose, pattern, and timing of prenatal alcohol exposure and achievement in reading, writing, spelling,... ...

        Research

        Maternal life stress events in pregnancy link to children's school achievement at age 10 years

        To test the hypothesis that maternal antenatal exposure to life stress events is associated with lower achievement in literacy and numeracy at age 10 years,... ...

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