Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive features. Here, we employed single-cell RNA sequencing, spatial transcriptomics and bulk RNA sequencing to delineate specific cell subsets involved in hepatocellular carcinoma  relapse and response to immunotherapy.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

The goal of the article is to support the early childhood sector's efforts to increase the salience of early childhood as a social issue and change policy and practice to better support young children and their families. Cultural models shape how people think about social issues and support solutions. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

We investigated immune and non-immune related genes to determine other factors required for the development of Abacavir hypersensitivity syndrome ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Findings suggest that TGF-Beta in milk may influence the development of immunological outcomes in offspring. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Our maps provide a baseline for measuring change and a mechanism to guide interventions during the era of the Sustainable Development Goals ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Yasmin Lizzie Harman-Smith Button YHS LB BA, BHlthSc(Hons), PhD BPsych (Hons) Head, Early Years Systems Evidence; Head, Tenders Support Unit Research Assistant 08 6375 9747 Yasmin.harman-smith@telethonkids.org.au elizabeth.button@ ...

• 1. Telethon Kids Institute
• Projects
• Past projects

Alanna Yasmin Sincovich Harman-Smith AS YHS BPsych(Hons), PhD BA, BHlthSc(Hons), PhD Senior Research Officer Head, Early Years Systems Evidence; Head, Tenders Support Unit 08 6375 6108 Alanna.sincovich@telethonkids.org.au Yasmin.harman-smith@ ...

• 1. Telethon Kids Institute
• Projects
• Past projects

Our results support a fundamental assumption that facial sexual dimorphism is an indicator of immune function during the development of facial sexual dimorphism ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

We begin with isotropic Gaussian random fields, and show how the Bochner-Godement theorem gives a natural way to describe their covariance structure. We continue with a study of Matérn processes on Euclidean space, spheres, manifolds and graphs, using Bessel potentials and stochastic partial differential equations (SPDEs). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Wearable motion sensors, specifically, Inertial Measurement Units, are useful tools for the assessment of orientation and movement during sleep. The DOTs platform (Xsens, Enschede, The Netherlands) has shown promise for this purpose. This pilot study aimed to assess its feasibility and validity for recording sleep biomechanics. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

Patterns of early childhood developmental vulnerabilities may provide useful indicators for particular mental disorder outcomes in later life ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018